| Autor: |
Wang X; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China.; University of Chinese Academy of Sciences, Beijing 100000, China., Jia JK; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China.; University of Chinese Academy of Sciences, Beijing 100000, China., Wang Q; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China.; University of Chinese Academy of Sciences, Beijing 100000, China., Gong JW; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China., Li A; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China.; State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical School, Guangzhou, Guangdong 510005, China., Su J; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China.; University of Chinese Academy of Sciences, Beijing 100000, China., Zhou P; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.; Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong 510005, China.; State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical School, Guangzhou, Guangdong 510005, China. E-mail: zhou_peng@gzlab.ac.cn. |
| Abstrakt: |
Bats, notable as the only flying mammals, serve as natural reservoir hosts for various highly pathogenic viruses in humans (e.g., SARS-CoV and Ebola virus). Furthermore, bats exhibit an unparalleled longevity among mammals relative to their size, particularly the Myotis bats, which can live up to 40 years. However, the mechanisms underlying these distinctive traits remain incompletely understood. In our prior research, we demonstrated that bats exhibit dampened STING-interferon activation, potentially conferring upon them the capacity to mitigate virus- or aging-induced inflammation. To substantiate this hypothesis, we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING ( Md STING) into the mouse genome. We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on Md STING and wild-type mice over a 3-year aging process. Blood transcriptomic analysis indicated a reduction in aging-related inflammation in female Md STING mice, as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines, immunopathology, and neutrophil recruitment in aged female Md STING mice compared to aged wild-type mice in vivo . These results indicated that Md STING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent manner. Although the underlying mechanism awaits further study, this research has critical implications for bat longevity research, potentially contributing to our comprehension of healthy aging in humans. |
