Distinct neural mechanisms for heading retrieval and context recognition in the hippocampus during spatial reorientation.

Autor: Gagliardi CM; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, 52245, USA., Normandin ME; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, 52245, USA., Keinath AT; Department of Psychology, University of Illinois Chicago, Chicago, IL, 60607, USA., Julian JB; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA., Lopez MR; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, 52245, USA., Ramos-Alvarez MM; Psychology Department, University of Jaen, Campus Las Lagunillas, Jaen, 23071, Spain., Epstein RA; Department of Psychology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Muzzio IA; Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, 52245, USA. isabel-muzzio@uiowa.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jul 16; Vol. 15 (1), pp. 5968. Date of Electronic Publication: 2024 Jul 16.
DOI: 10.1038/s41467-024-50112-7
Abstrakt: Reorientation, the process of regaining one's bearings after becoming lost, requires identification of a spatial context (context recognition) and recovery of facing direction within that context (heading retrieval). We previously showed that these processes rely on the use of features and geometry, respectively. Here, we examine reorientation behavior in a task that creates contextual ambiguity over a long timescale to demonstrate that male mice learn to combine both featural and geometric cues to recover heading. At the neural level, most CA1 neurons persistently align to geometry, and this alignment predicts heading behavior. However, a small subset of cells remaps coherently in a context-sensitive manner, which serves to predict context. Efficient heading retrieval and context recognition correlate with rate changes reflecting integration of featural and geometric information in the active ensemble. These data illustrate how context recognition and heading retrieval are coded in CA1 and how these processes change with experience.
(© 2024. The Author(s).)
Databáze: MEDLINE
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