The Effects of Cycle Ergometer Versus Treadmill Exercise Stress Testing on QTc Interval Prolongation in Patients With Long QT Syndrome: A Systematic Review and Meta-analysis.

Autor:	Harvey A; Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal, Montreal, Canada.; Sainte-Justine University Health Center, Research Center, Montreal, Canada., Curnier D; Laboratory of Pathophysiology of EXercise (LPEX), School of Kinesiology and Physical Activity Sciences, Faculty of Medicine, University of Montreal, Montreal, Canada.; Sainte-Justine University Health Center, Research Center, Montreal, Canada., Dodin P; Sainte-Justine University Health Center, Research Center, Montreal, Canada., Jacquemet V; Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, Canada ; and., Caru M; Department of Pediatrics and Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.
Jazyk:	angličtina
Zdroj:	Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine [Clin J Sport Med] 2024 Sep 01; Vol. 34 (5), pp. 474-502. Date of Electronic Publication: 2024 Jul 16.
DOI:	10.1097/JSM.0000000000001256
Abstrakt:	Objective: The safest and most effective exercise stress tests (EST) modalities for long QT syndrome (LQTS) are currently unknown. The main objective was to explore the effects of EST on the corrected QT interval (QTc) in patients with LQTS, and to compare the effects of different EST modalities (cycle ergometer vs treadmill). Data Sources: Systematic searches were performed in September 2022 in accordance with the PRISMA statement through PubMed, Medline, EBM Reviews, Embase, and Web of Science. Main Results: A total of 1728 patients with LQTS, whether congenital or acquired, without any age restrictions (pediatric age ≤18 years and adult age >19 years), and 2437 control subjects were included in the 49 studies. The QT interval data were available for 15 studies. Our analyses showed that the QT interval prolonged in a similar manner using either a cycle ergometer or a treadmill (standardized mean difference [SMD] = 1.89 [95% CI, 1.07-2.71] vs SMD = 1.46 [95% CI, 0.78-2.14], respectively). Therefore, it seems that either modality may be used to evaluate patients with LQTS. Conclusions: The methodology for the measurement of the QT interval was very heterogeneous between studies, which inevitably influenced the quality of the analyses. Hence, researchers should proceed with caution when exploring and interpreting data in the field of exercise and LQTS. Competing Interests: A. Harvey, D. Curnier, P. Dodin, V. Jacquemet, and M. Caru declare that they have no conflict of interest. The authors report no relationships that could be construed as a conflict of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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