| Autor: |
Potužník JF; Institute of Organic Chemistry and Biochemistry of the CAS, Prague 6, Czechia.; Department of Cell Biology, Charles University, Faculty of Science, Prague 2, Czechia., Cahova H; Institute of Organic Chemistry and Biochemistry of the CAS, Prague 6, Czechia. |
| Jazyk: |
angličtina |
| Zdroj: |
RNA biology [RNA Biol] 2024 Jan; Vol. 21 (1), pp. 1-13. Date of Electronic Publication: 2024 Jul 15. |
| DOI: |
10.1080/15476286.2024.2372138 |
| Abstrakt: |
RNA capping is a prominent RNA modification that influences RNA stability, metabolism, and function. While it was long limited to the study of the most abundant eukaryotic canonical m 7 G cap, the field recently went through a large paradigm shift with the discovery of non-canonical RNA capping in bacteria and ultimately all domains of life. The repertoire of non-canonical caps has expanded to encompass metabolite caps, including NAD, FAD, CoA, UDP-Glucose, and ADP-ribose, alongside alarmone dinucleoside polyphosphate caps, and methylated phosphate cap-like structures. This review offers an introduction into the field, presenting a summary of the current knowledge about non-canonical RNA caps. We highlight the often still enigmatic biological roles of the caps together with their processing enzymes, focusing on the most recent discoveries. Furthermore, we present the methods used for the detection and analysis of these non-canonical RNA caps and thus provide an introduction into this dynamic new field. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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