Pediatric dentistry systematic reviews using the GRADE approach: methodological study.

Autor: Alvarenga-Brant R; Department of Surgery, Clinical Dentistry and Oral Pathology and Oral Surgery, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil., Notaro SQ; Department of Pediatric Dentistry, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil., Stefani CM; Department of Dentistry, University of Brasília, Brasília, DF, Brazil., De Luca Canto G; Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil., Pereira AG; Department of Surgery, Clinical Dentistry and Oral Pathology and Oral Surgery, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil., Póvoa-Santos L; Department of Pediatric Dentistry, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil., Souza-Oliveira AC; Department of Pediatric Dentistry, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil., Campos JR; Department of Surgery, Clinical Dentistry and Oral Pathology and Oral Surgery, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil., Martins-Pfeifer CC; Department of Pediatric Dentistry, Dental School, Federal University of Minas Gerais, Belo Horizonte, Brazil. carolcm10@hotmail.com.
Jazyk: angličtina
Zdroj: BMC oral health [BMC Oral Health] 2024 Jul 13; Vol. 24 (1), pp. 787. Date of Electronic Publication: 2024 Jul 13.
DOI: 10.1186/s12903-024-04542-w
Abstrakt: Background: To assess the reporting of the certainty of the evidence using the GRADE approach in systematic reviews of interventions in pediatric dentistry.
Methods: The inclusion criteria were systematic reviews of randomized clinical trials (RCTs) and non-randomized studies of interventions (NRSIs) in pediatric dentistry that reported the certainty of the evidence through the GRADE approach. Paired independent reviewers screened the studies, extracted data, and appraised the methodological quality using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR 2) tool. The certainty of the evidence was extracted for each outcome. A descriptive analysis was conducted.
Results: Around 28% of pediatric dentistry reviews of interventions used the GRADE approach (n = 24). Twenty reviews reported 112 evidence outcomes from RCTs and 13 from NRSIs using GRADE evidence profile tables. The methodological quality was high (16.7%), moderate (12.5%), low (37.5%), and critically low (33.3%), fulfilling the majority of the AMSTAR 2 criteria. The certainty of the evidence for outcomes generated from RCTs and NRSIs was very low (40.2% and 84.6%), low (33.1% and 7.7%), moderate (17.8% and 7.7%), and high (9.8% and 0.0%). The main reasons to downgrade the certainty were due to (for RCTs and NRSIs, respectively): risk of bias (68.8% and 84.6%), imprecision (67.8% and 100.0%), inconsistency (18.8% and 23.1%), indirectness (17.8% and 0.0%), and publication bias (7.1% and 0.0%).
Conclusion: The proportion of systematic reviews assessing the certainty of the evidence using the GRADE approach was considered small, considering the total initial number of published pediatric dentistry reviews of intervention. The certainty of the evidence was mainly very low and low, and the main problems for downgrading the certainty of evidence were due to risk of bias and imprecision.
Registration: PROSPERO database #CRD42022365443.
(© 2024. The Author(s).)
Databáze: MEDLINE
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