Clinical and pharmacogenetic features of patients with upper gastrointestinal lesions at a multidisciplinary hospital: the role of nonsteroidal anti-inflammatory drugs.

Autor: Denisenko NP; Research Institute of Molecular and Personalized Medicine, 442138 Russian Medical Academy of Continuous Professional Education , Moscow, Russian Federation., Zhiryakova AS; Department of Clinical Pharmacology and Therapeutics named after Academician B.E. Votchal, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.; Department of Clinical pharmacology, Municipal Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation., Sychev IV; Research Institute of Molecular and Personalized Medicine, 442138 Russian Medical Academy of Continuous Professional Education , Moscow, Russian Federation., Kryukov AV; Department of Clinical Pharmacology and Therapeutics named after Academician B.E. Votchal, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.; Department of Clinical pharmacology, Municipal Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation., Tuchkova SN; Research Institute of Molecular and Personalized Medicine, 442138 Russian Medical Academy of Continuous Professional Education , Moscow, Russian Federation., Vakulenko OY; Clinical Diagnostic Department, Municipal Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation., Averkov OV; The Regional Vascular Center, Municipal Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation., Vechorko VI; Municipal Clinical Hospital No. 15 named after O.M. Filatov, Moscow, Russian Federation., Mirzaev KB; Research Institute of Molecular and Personalized Medicine, 442138 Russian Medical Academy of Continuous Professional Education , Moscow, Russian Federation., Sychev DA; Department of Clinical Pharmacology and Therapeutics named after Academician B.E. Votchal, Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
Jazyk: angličtina
Zdroj: Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2024 Jul 15; Vol. 39 (2), pp. 69-79. Date of Electronic Publication: 2024 Jul 15 (Print Publication: 2024).
DOI: 10.1515/dmpt-2024-0040
Abstrakt: Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed medications, but their use can be associated with a number of adverse reactions, including upper gastrointestinal lesions. The aim of the study was to identify clinical and pharmacogenetic factors associated with upper gastrointestinal lesions, including those linked to NSAIDs, in patients at a multidisciplinary hospital.
Methods: The study included 92 patients (mean age 59.4±16.5 years; 47 women), who underwent esophagogastroduodenoscopy during inpatient treatment. Patients' intake of NSAIDs and gastroprotectors during the year before hospitalization was considered. Demographic, clinical, laboratory data of patients were compared between groups, including genotyping for CYP2C9*2 rs179985 , CYP2C9*3 rs1057910 , CYP2C8*3 rs11572080 , CYP2C8*3 rs10509681 , PTGS-1 rs10306135 , PTGS-1 rs12353214 , and PTGS-2 rs20417 using real-time PCR.
Results: In NSAIDs + patients, PTGS1 rs10306135 AT+TT genotypes increased the chance of developing gastrointestinal complications by 5.4 times (95 % CI=1.30-22.27). In total sample, smoking (OR=3.12, 95 % CI=1.15-8.46), and alcohol intake (OR=4.09, 95 % CI=1.05-15.87) increased odds of gastrointestinal damage. In NSAIDs + patients omeprazole, famotidine and both famotidine and omeprazole during the last year were as ineffective as not taking gastroprotectors; in total sample famotidine (OR=0.19, 95 % CI=0.04-0.93) and two gastroprotectors (OR=0.13, 95 % CI=0.02-0.75) reduced the chance of upper gastrointestinal lesions.
Conclusions: Pharmacogenetic features of patients may significantly contribute to the development NSAIDs-induced upper gastrointestinal injuries.
(© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze: MEDLINE
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