LncRNA SNHG5/IGF2BP1/Occludin axis regulates Nd 2 O 3 induced blood-testis barrier disruption.

Autor: Wang S; School of Public Health, Baotou Medical College, Baotou, 014030, Inner Mongolia, PR China., Ma Y; School of Public Health, Baotou Medical College, Baotou, 014030, Inner Mongolia, PR China., Li W; School of Public Health, Baotou Medical College, Baotou, 014030, Inner Mongolia, PR China., Zhao Y; School of Public Health, Baotou Medical College, Baotou, 014030, Inner Mongolia, PR China., Gao Y; School of Public Health, Baotou Medical College, Baotou, 014030, Inner Mongolia, PR China., Wang S; School of Public Health, Baotou Medical College, Baotou, 014030, Inner Mongolia, PR China. Electronic address: bt_wangsuhua@163.com.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Oct 01; Vol. 358, pp. 124527. Date of Electronic Publication: 2024 Jul 09.
DOI: 10.1016/j.envpol.2024.124527
Abstrakt: Neodymium oxide (Nd 2 O 3 ) is a rare earth element that can lead to various type of tissue and organ damage with prolonged exposure. The long noncoding RNA small nucleolar ribonucleic acid host gene 5 (lncRNA SNHG5) plays a role in disease progressiong. However, its connection with Nd 2 O 3 induced reproductive harm in males has not been thoroughly investigated. Our research discovered that exposure to Nd 2 O 3 increases the expression of SNHG5 in the testes of mice, which in turn binds directly to and reduces in the protein levels of insulin like growth factor 2 mRNA-binding protein 1 (IGF2BP1) both in vivo and in vitro. This process disrupts the cytoskeleton of blood-testis barrier(BTB) by impacting the stability of the tight junction protein Occludin (Ocln) mRNA structure and the permeability of the BTB. In summary, our study elucidates the regulatory mechanism of SNHG5/IGF2BP1/Occludin axis in Nd 2 O 3 -induced BTB injury, providing valuable insights for the treatment of male infertility.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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