A comparison of clinical characteristics and course predictors in early- and childhood-onset schizophrenia.

Autor: Baykal S; Department of Child and Adolescent Psychiatry, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Bozkurt A; Department of Child and Adolescent Psychiatry, Atatürk University Faculty of Medicine, Erzurum, Turkey., Çobanoğlu Osmanlı C; Department of Child and Adolescent Psychiatry, Giresun University, Faculty of Medicine, Giresun, Turkey., Önal BS; Department of Child and Adolescent Psychiatry, Giresun University, Faculty of Medicine, Giresun, Turkey., Şahin B; Department of Child and Adolescent Psychiatry, Giresun University, Faculty of Medicine, Giresun, Turkey., Karadoğan ZN; Child and Adolescent Psychiatrist, Erzincan Binali Yıldırım University, Mengücek Gazi Training and Research Hospital, Erzincan, Turkey., Karadağ M; Department of Child and Adolescent Psychiatry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey., Hangül Z; Zehra HANGÜL, Child and Adolescent Psychiatry Clinic, Adana, Turkey., Kılıçaslan F; Department of Child and Adolescent Psychiatry, Harran University, Faculty of Medicine, Sanliurfa, Turkey., Ayaydın H; Child and Adolescent Psychiatrist, Yeniyüzyıl University School of Medicine, İstanbul, Turkey., Uzun N; Department of Child and Adolescent Psychiatry, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey., Demirdöğen EY; Department of Child and Adolescent Psychiatry, Atatürk University Faculty of Medicine, Erzurum, Turkey., Akıncı MA; Department of Child and Adolescent Psychiatry, Atatürk University Faculty of Medicine, Erzurum, Turkey., Bilaç Ö; Department of Child and Adolescent Psychiatry, Manisa Celal University School of Medicine, Manisa, Turkey., Büber A; Department of Child and Adolescent Psychiatry, Pamukkale University Faculty of Medicine, Denizli, Turkey., Tufan AE; Department of Child and Adolescent Psychiatry, Bolu Abant İzzet Baysal University Faculty of Medicine, Turkey., Aksu GG; Associate Professor Doctor, Department of Child and Adolescent Psychiatry, Mersin University School of Medicine, Mersin, Turkey., Taner HA; Department of Child and Adolescent Psychiatry, Başkent University Faculty of Medicine, Ankara, Turkey., Sarı BA; Department of Child and Adolescent Psychiatry, Başkent University Faculty of Medicine, Ankara, Turkey., Kütük MÖ; Department of Child and Adolescent Psychiatry, Baskent University Faculty of Medicine, Adana Dr. Turgut Noyan Medical and Research Center, Adana, Turkey., Kaba D; Department of Child and Adolescent Psychiatry, Başkent University Faculty of Medicine, Ankara, Turkey., Karaçizmeli M; Department of Child and Adolescent Psychiatry, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Kavcıoğlu R; Department of Child and Adolescent Psychiatry, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Görker I; Department of Child and Adolescent Psychiatry, Trakya University Faculty of Medicine, Edirne, Turkey., Karabekiroğlu K; Department of Child and Adolescent Psychiatry, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.
Jazyk: angličtina
Zdroj: Early intervention in psychiatry [Early Interv Psychiatry] 2024 Jul 11. Date of Electronic Publication: 2024 Jul 11.
DOI: 10.1111/eip.13594
Abstrakt: Aim: The aim of this study was to compare the clinical characteristics of childhood-onset schizophrenia (COS) and early-onset schizophrenia (EOS) during the first- episode psychosis and the stable period, to examine psychopharmacological treatment approaches, and to investigate potential predictive factors for prognosis.
Methods: Demographic, clinical, and psychopharmacological therapy data for 31 patients diagnosed with COS and 66 with EOS were retrieved from the file records in this multicenter study. Symptom distribution and disease severity and course were evaluated twice, in the acute psychotic stage and in the latest stable phase, during follow-up using the positive and negative syndrome scale (PANSS) and clinical global impression (CGI) scales.
Results: A statistically significant difference was observed between the groups' CGI improvement rates and median last stable stage PANSS positive, negative, and general psychopathology symptom scores (p = .005, p = .031, p = .005, and p = .012, respectively). Premorbid neurodevelopmental disorder and obsessive-compulsive disorder and comorbidities were more common in the COS group (p = .025 and p = .030, respectively), and treatment required greater multiple antipsychotic use in that group (p = .013). When the independent variables affecting the difference between pre- and post-treatment PANSS scores were examined using linear regression analysis, the model established was found to be statistically significant (F = 5.393; p = .001), and the group variable (p = .024), initial disease severity (p = .001), and socioeconomic level (p = .022; p = .007) emerged as predictive factors for the disease course.
Conclusion: Although early diagnosis and treatment is an important factor in improving prognosis in schizophrenia, more specific predictors for schizophrenia need to be identified. Additionally, preventive programs and pharmacological methods need to be developed in children with neurodevelopmental problems, particularly those from low socioeconomic status families.
(© 2024 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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