Pelvic ultrasound and pubertal attainment in girls with sexual precocity: the pivotal role of uterine volume in predicting the timing of menarche.
| Autor: | Cattoni A; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy., Russo G; Department of Pediatrics, Endocrine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Capitoli G; School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy.; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Rodari G; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Nicolosi ML; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Molinari S; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Tondelli D; School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy.; Bicocca Bioinformatics, Biostatistics and Bioimaging B4 Centre, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy., Pelliccia C; Department of Pediatrics, Ospedale Papa Giovanni XXIII, Bergamo, Italy., Radaelli S; Department of Pediatrics, Ospedale Papa Giovanni XXIII, Bergamo, Italy., Arosio AML; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Fontana K; Department of Pediatrics, Endocrine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Tattesi G; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Passoni P; Department of Gynecology and Obstetrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Boneschi A; Department of Gynecology and Obstetrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Giavoli C; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.; Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Meroni SLC; Department of Pediatrics, Endocrine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Stancampiano MR; Department of Pediatrics, Endocrine Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Garuti E; Department of Radiology, IRCCS San Raffaele Scientific Institute, Milan, Italy., Biondi A; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy., Balduzzi A; Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, Milano-Bicocca University, Monza, Italy., Bizzarri C; Unit of Pediatric Endocrinology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Jun 25; Vol. 15, pp. 1417281. Date of Electronic Publication: 2024 Jun 25 (Print Publication: 2024). |
| DOI: | 10.3389/fendo.2024.1417281 |
| Abstrakt: | Introduction: Among girls assessed for pubertal precocity, pelvic ultrasound (pUS) may represent a pivotal tool to predict the time expected to elapse between sonographic assessment and the onset of menarche (T Methods: Retrospective, multicenter analysis. Girls assessed for sexual precocity and showing sonographic and clinical findings consistent with pubertal onset upon referral were considered eligible. Patients treated with GnRH analogues were excluded and only those who had subsequently achieved complete and spontaneous pubertal attainment and for whom the exact date of menarche was available were included. Overall, we enrolled 184 girls from five tertiary care Italian Centers. Results: The time elapsed (months) between baseline endocrine assessment and spontaneous achievement of menarche showed a negative statistically significant correlation ( p <0.0001) with LH (r:-0.61), FSH (r:-0.59), estradiol (r:-0.52) and stimulated LH values (r:-0.58). Among pUS parameters, ovarian volume (r:-0.17 left, -0.30 right) and uterine body-to-cervix ratio (r:-0.18) poorly correlated with T Conclusion: The logarithm of UV shows the best statistical performance in predicting the timing of menarche in girls assessed for pubertal precocity. Accordingly, we developed a user-friendly online application that provides clinicians with an estimation of the months expected to elapse before menarche, based on the UV recorded upon pUS. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Cattoni, Russo, Capitoli, Rodari, Nicolosi, Molinari, Tondelli, Pelliccia, Radaelli, Arosio, Fontana, Tattesi, Passoni, Boneschi, Giavoli, Meroni, Stancampiano, Garuti, Biondi, Balduzzi and Bizzarri.) |
| Databáze: | MEDLINE |
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