Insufficient Plasma Melatonin and Its Association With Neuropsychiatric Impairments in Patients With T2DM.

Autor: He S; School of Pharmacy Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China.; The Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of Education Anhui Medical University, Hefei, China.; Anhui Provincial Laboratory of Inflammatory and Immunity Disease Anhui Institute of Innovative Drugs, Hefei, China., Yu Y; Department of Pharmacy North District of The First Affiliated Hospital of Anhui Medical University, Hefei, China., Chen PQ; School of Pharmacy Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China.; The Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of Education Anhui Medical University, Hefei, China.; Anhui Provincial Laboratory of Inflammatory and Immunity Disease Anhui Institute of Innovative Drugs, Hefei, China., Sun HM; School of Pharmacy Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China.; The Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of Education Anhui Medical University, Hefei, China.; Anhui Provincial Laboratory of Inflammatory and Immunity Disease Anhui Institute of Innovative Drugs, Hefei, China., Gao XR; School of Pharmacy Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China.; The Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of Education Anhui Medical University, Hefei, China.; Anhui Provincial Laboratory of Inflammatory and Immunity Disease Anhui Institute of Innovative Drugs, Hefei, China., Sun HZ; School of Pharmacy Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China.; The Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of Education Anhui Medical University, Hefei, China.; Anhui Provincial Laboratory of Inflammatory and Immunity Disease Anhui Institute of Innovative Drugs, Hefei, China., Ge JF; School of Pharmacy Anhui Medical University, 81 Mei-Shan Road, Hefei 230032, China.; The Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of Education Anhui Medical University, Hefei, China.; Anhui Provincial Laboratory of Inflammatory and Immunity Disease Anhui Institute of Innovative Drugs, Hefei, China.
Jazyk: angličtina
Zdroj: Journal of diabetes research [J Diabetes Res] 2024 Jul 03; Vol. 2024, pp. 5661751. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024).
DOI: 10.1155/2024/5661751
Abstrakt: Purpose: Type 2 diabetes mellitus (T2DM) is associated with multiple neuropsychiatric impairments, including cognitive dysfunction, and melatonin (MLT) plays a crucial role in maintaining normal neuropsychiatric functions. This study is aimed at investigating the change in plasma MLT levels and its association with neuropsychiatric impairments in T2DM patients. Methods: One hundred twenty-six T2DM patients were recruited, and their demographics and clinical data were collected. Apart from the plasma glycated hemoglobin (HbA1c) levels and other routine metabolic indicators, the plasma concentrations of MLT, C-reactive protein (CRP), Interleukin 6 (IL-6), soluble myeloid triggered receptor 1 (sTREM 1), and receptor 2 (sTREM 2) were measured. Moreover, the executive function and depressive tendency were evaluated via the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) and the Epidemiological Research Center Depression Scale (CES-D), respectively. Result: Compared with the low HbA1c group, the T2DM patients in the high HbA1c group presented lower plasma MLT levels but higher plasma concentrations of inflammatory biomarker levels, together with higher scores in the BRIEF-A and CES-D scales. Moreover, results of the Pearson correlation test showed that the plasma MLT levels were negatively correlated with the BRIEF-A and CES-D scores, as well as plasma concentrations of HbA1c and inflammatory indications, indicating that MLT may mediate their neuroinflammation and neuropsychiatric impairments. Furthermore, the ROC curve results indicated that plasma MLT levels have a predictive effect on executive impairment and depressive status in T2DM patients. Conclusion: MLT levels decreased in patients with T2DM and were associated with neuropsychiatric impairments and inflammatory status, and MLT might be developed as a therapeutic agent and predictive indicator for T2DM-associated executive impairment and depression status.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2024 Shuai He et al.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje