Computational Mechanisms Underlying Multi-Step Planning Deficits in Methamphetamine Use Disorder.

Autor:	Lavalley CA; Laureate Institute for Brain Research, Tulsa, OK, United States., Mehta MM; University of Tulsa, Tulsa, OK, United States., Taylor S; Laureate Institute for Brain Research, Tulsa, OK, United States., Chuning AE; Laureate Institute for Brain Research, Tulsa, OK, United States., Stewart JL; Laureate Institute for Brain Research, Tulsa, OK, United States.; University of Tulsa, Tulsa, OK, United States., Huys QJM; Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom., Khalsa SS; Laureate Institute for Brain Research, Tulsa, OK, United States.; University of Tulsa, Tulsa, OK, United States., Paulus MP; Laureate Institute for Brain Research, Tulsa, OK, United States.; University of Tulsa, Tulsa, OK, United States., Smith R; Laureate Institute for Brain Research, Tulsa, OK, United States.; University of Tulsa, Tulsa, OK, United States.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 28. Date of Electronic Publication: 2024 Jun 28.
DOI:	10.1101/2024.06.27.24309581
Abstrakt:	Current theories suggest individuals with methamphetamine use disorder (iMUDs) have difficulty considering long-term outcomes in decision-making, which could contribute to risk of relapse. Aversive interoceptive states (e.g., stress, withdrawal) are also known to increase this risk. The present study analyzed computational mechanisms of planning in iMUDs, and examined the potential impact of an aversive interoceptive state induction. A group of 40 iMUDs and 49 healthy participants completed two runs of a multi-step planning task, with and without an anxiogenic breathing resistance manipulation. Computational modeling revealed that iMUDs had selective difficulty identifying the best overall plan when this required enduring negative short-term outcomes - a mechanism referred to as aversive pruning. Increases in reported craving before and after the induction also predicted greater aversive pruning in iMUDs. These results highlight a novel mechanism that could promote poor choice in recovering iMUDs and create vulnerability to relapse. Competing Interests: Conflict of interest or competing financial interests The authors have no conflicts of interest to report.
Databáze:	MEDLINE
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