Skeletal effects of sleeve gastrectomy, by sex and menopausal status and in comparison to Roux-en-Y gastric bypass surgery.

Autor:	Wu KC; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., Wu PH; Department of Radiology, University of California San Francisco, San Francisco, CA, USA., Kazakia G; Department of Radiology, University of California San Francisco, San Francisco, CA, USA., Patel S; California Pacific Medical Center Research Institute, San Francisco, CA, USA., Black DM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA., Lang TF; Department of Radiology, University of California San Francisco, San Francisco, CA, USA., Kim TY; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., King NJ; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., Hoffman TJ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Chang H; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA., Linfield G; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Palilla S; Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Rogers SJ; Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Carter JT; Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Posselt AM; Department of Surgery, University of California San Francisco, San Francisco, CA, USA., Schafer AL; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.
DOI:	10.1101/2024.06.25.24309368
Abstrakt:	Context: Roux-en-Y gastric bypass (RYGB) has deleterious effects on bone mass, microarchitecture, and strength. Data are lacking on the skeletal effects of sleeve gastrectomy (SG), now the most commonly performed bariatric surgical procedure. Objective: We examined changes in bone turnover, areal and volumetric bone mineral density (aBMD, vBMD), and appendicular bone microarchitecture and estimated strength after SG. We compared the results to those previously reported after RYGB, hypothesizing lesser effects after SG than RYGB. Design Setting Participants: Prospective observational cohort study of 54 adults with obesity undergoing SG at an academic center. Main Outcome Measures: Skeletal characterization with biochemical markers of bone turnover, dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT), and high-resolution peripheral QCT (HR-pQCT) was performed preoperatively and 6- and 12-months postoperatively. Results: Over 12 months, mean percentage weight loss was 28.8%. Bone turnover marker levels increased, and total hip aBMD decreased -8.0% (95% CI -9.1%, -6.7%, p<0.01). Spinal aBMD and vBMD declines were larger in postmenopausal women than men. Tibial and radial trabecular and cortical microstructure worsened, as did tibial estimated strength, particularly in postmenopausal women. When compared to data from a RYGB cohort with identical design and measurements, some SG biochemical, vBMD, and radial microstructural parameters were smaller, while other changes were not. Conclusions: Bone mass, microstructure, and strength decrease after SG. Some skeletal parameters change less after SG than after RYGB, while for others, we find no evidence for smaller effects after SG. Postmenopausal women may be at highest risk of skeletal consequences after SG.
Databáze:	MEDLINE
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