Pathogenicity and transmissibility of bovine H5N1 influenza virus.

Autor: Eisfeld AJ; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Biswas A; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Guan L; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Gu C; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Maemura T; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Trifkovic S; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Wang T; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Babujee L; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Dahn R; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Halfmann PJ; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Barnhardt T; Heritage Vet Partners, Johnson, KS, USA., Neumann G; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Suzuki Y; Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan., Thompson A; Texas A&M Veterinary Medical Diagnostic Laboratory, Canyon, TX, USA., Swinford AK; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Dimitrov KM; Texas A&M Veterinary Medical Diagnostic Laboratory, College Station, TX, USA., Poulsen K; Wisconsin Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, WI, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.; Department of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Sep; Vol. 633 (8029), pp. 426-432. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1038/s41586-024-07766-6
Abstrakt: Highly pathogenic H5N1 avian influenza (HPAI H5N1) viruses occasionally infect, but typically do not transmit, in mammals. In the spring of 2024, an unprecedented outbreak of HPAI H5N1 in bovine herds occurred in the USA, with virus spread within and between herds, infections in poultry and cats, and spillover into humans, collectively indicating an increased public health risk 1-4 . Here we characterize an HPAI H5N1 virus isolated from infected cow milk in mice and ferrets. Like other HPAI H5N1 viruses, the bovine H5N1 virus spread systemically, including to the mammary glands of both species, however, this tropism was also observed for an older HPAI H5N1 virus isolate. Bovine HPAI H5N1 virus bound to sialic acids expressed in human upper airways and inefficiently transmitted to exposed ferrets (one of four exposed ferrets seroconverted without virus detection). Bovine HPAI H5N1 virus thus possesses features that may facilitate infection and transmission in mammals.
(© 2024. The Author(s).)
Databáze: MEDLINE
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