Association between maternal HIV status and postpartum depressive symptoms in Botswana.

Autor: Mmasa KN; County Durham and Darlington NHS Trust, Centre for Clinical Research and Innovation, Darlington Memorial Hospital, Darlington, UK.; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana., Liu Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Jao J; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana.; Department of Pediatrics, Division of Pediatric Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Malee K; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Legbedze J; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Sun S; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Kgole S; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana., Masasa G; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana., Mmalane M; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana., Makhema J; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana., Mafa N; Mental Health Department, Ministry of Health and Wellness, Gaborone, Botswana., Abrams EJ; ICAP, Mailman School of Public Health, Columbia University, New York, NY, USA.; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA., Powis KM; Botswana-Harvard Health Institute Partnership, Gaborone, Botswana.; Department of Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bonner LB; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Pediatrics, Division of Pediatric Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: AIDS care [AIDS Care] 2024 Jul 08, pp. 1-6. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1080/09540121.2024.2373398
Abstrakt: Few studies have evaluated postpartum depression (PPD) in women living with HIV (WLHIV) in Botswana, a high prevalence HIV setting. The Edinburgh Postnatal Depression Scale (EPDS) was used to evaluate PPD symptoms in WLHIV ( n  = 300) and women who are HIV-uninfected ( n  = 131) in the Tshilo Dikotla study, an observational cohort study with a nested randomized trial. The EPDS was administered at 2, 6, and 12 months postpartum. We assessed the association of (1) HIV infection and (2) antiretroviral therapy (ART) with odds of PPD symptoms (EPDS ≥ 10 or thoughts of self-harm) in the first year postpartum using generalized estimating equations. Of WLHIV, 24 (8.00%) had PPD symptoms at one or more follow-up time points, compared to 9 (6.9%) women who were HIV-seronegative. There was no association between HIV status and PPD symptoms (adjusted odds ratio [aOR]:1.69, 95% confidence interval [CI]: 0.73-3.93, p  = 0.225); however, WLHIV on efavirenz-based ART regimens had higher odds of experiencing PPD symptoms compared to dolutegravir-based ART (aOR:3.05, 95% CI:1.16-8.03, p  = 0.024).
Databáze: MEDLINE