Food-Pollen Cross-Reactivity and its Molecular Diagnosis in China.

Autor: Zhao L; Allergy Research Center, Zhejiang University, Hangzhou, 310058, China., Ma T; Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China., Wang X; Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China., Wang H; Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China., Liu Y; Hangzhou Zheda Dixun Biological Gene Engineering Co. Ltd, Hangzhou, China., Wu S; Hangzhou Zheda Dixun Biological Gene Engineering Co. Ltd, Hangzhou, China., Fu L; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China., Gilissen L; Plant Breeding, Wageningen University & Research, Wageningen, The Netherlands., van Ree R; Departments of Experimental Immunology and of Otorhinolaryngology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Wang X; Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. wangxueyan2018@163.com., Gao Z; Allergy Research Center, Zhejiang University, Hangzhou, 310058, China. gaozhongshan@zju.edu.cn.; Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. gaozhongshan@zju.edu.cn.; Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou, 310058, China. gaozhongshan@zju.edu.cn.
Jazyk: angličtina
Zdroj: Current allergy and asthma reports [Curr Allergy Asthma Rep] 2024 Sep; Vol. 24 (9), pp. 497-508. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.1007/s11882-024-01162-w
Abstrakt: Purpose of Review: Plant-derived foods are one of the most common causative sources of food allergy in China, with a significant relationship to pollinosis. This review aims to provide a comprehensive overview of this food-pollen allergy syndrome and its molecular allergen diagnosis to better understand the cross-reactive basis.
Recent Findings: Food-pollen cross-reactivity has been mainly reported in Northern China, Artemisia pollen is the major related inhalant source, followed by tree pollen (Betula), while grass pollen plays a minor role. Pollen allergy is relatively low in Southern China, with allergies to grass pollen being more important than weed and tree pollens. Rosaceae fruits and legume seeds stand out as major related allergenic foods. Non-specific lipid transfer protein (nsLTP) has been found to be the most clinically relevant cross-reacting allergenic component, able to induce severe reactions. PR-10, profilin, defensin, chitinase, and gibberellin-regulated proteins are other important cross-reactive allergen molecules. Artemisia pollen can induce allergenic cross-reactions with a wide range of plant-derived foods in China, and spring tree pollens (Betula) are also important. nsLTP found in both pollen and plant-derived food is considered the most significant allergen in food pollen cross-reactivity. Component-resolved diagnosis with potential allergenic proteins is recommended to improve diagnostic accuracy and predict the potential risk of causing allergic symptoms.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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