GATA4 is diagnostically useful for distinguishing primary ovarian mucinous carcinomas from metastatic colorectal adenocarcinomas to the ovary.

Autor:	Mochizuki K; Department of Pathology, University of Yamanashi, Chuo, Japan. kuniom@yamanashi.ac.jp., Tahara I; Department of Pathology, University of Yamanashi, Chuo, Japan., Inoue T; Department of Pathology, University of Yamanashi, Chuo, Japan., Kasai K; Department of Pathology, University of Yamanashi, Chuo, Japan., Kondo T; Department of Pathology, University of Yamanashi, Chuo, Japan.
Jazyk:	angličtina
Zdroj:	Histology and histopathology [Histol Histopathol] 2024 Jun 18, pp. 18783. Date of Electronic Publication: 2024 Jun 18.
DOI:	10.14670/HH-18-783
Abstrakt:	Aim: Determining the primary origin of an ovarian mucin-producing carcinoma can be challenging at times because some metastases of primary colorectal origin may exhibit gross, microscopic, and/or immunohistochemical features that overlap with those of primary ovarian mucinous carcinomas (OMCs). We hypothesized that GATA binding protein 4 (GATA4) might be a novel, useful marker for differentiating primary OMCs from metastatic colorectal adenocarcinomas to the ovary. Methodology: For comparison with the usefulness of other markers (special AT-rich sequence-binding protein 2 (SATB2) and caudal type homeobox 2 (CDX2)), we elucidated the expression profiles of GATA4 in OMCs, colorectal non-mucinous adenocarcinomas (CNMACs), and colorectal mucinous adenocarcinomas (CMACs) using immunohistochemistry. Results: We confirmed GATA4 expression (H-score ≥50 points) in 93%, SATB2 in 0%, and CDX2 in 64% of 14 OMCs. GATA4 was expressed in 13%, SATB2 in 90%, and CDX2 in 93% of 30 CNMACs. GATA4 was expressed in 20%, SATB2 in 73%, and CDX2 in 100% of 30 CMACs. Conclusion: The expression of GATA4 in a mucus-producing ovarian tumor strongly supports it being a primary OMC rather than a metastatic colorectal carcinoma: GATA4 expression indicates OMC and SATB2 expression indicates colorectal adenocarcinoma. However, three cases of colorectal adenocarcinoma were GATA4-positive and SATB2-negative, so the GATA4/SATB2 marker combination is not absolute for determining the primary site. Further research for more markers is necessary to find the ideal combination. (©The Author(s) 2024. Open Access. This article is licensed under a Creative Commons CC-BY International License.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu