Electrical Stimulation: How It Works and How to Apply It.
| Autor: | Senger JL; Division of Plastic Surgery, University of British Columbia, Suite 1788, 1111 W Georgia Street, Vancouver, British Columbia, V6E 4M3, Canada., Power H; Division of Plastic Surgery, Department of Surgery, University of Alberta, Suite 401, 316 Windermere Road NorthWest, Edmonton, Alberta T6W 2Z8, Canada., Moore AM; Department of Plastic and Reconstructive Surgery, The Ohio State University, 915 Olentangy River Road Suite 2100, Columbus, OH 43212, USA. Electronic address: amy.m.moore@osumc.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Hand clinics [Hand Clin] 2024 Aug; Vol. 40 (3), pp. 409-420. Date of Electronic Publication: 2024 May 19. |
| DOI: | 10.1016/j.hcl.2024.03.007 |
| Abstrakt: | Electrical stimulation is emerging as a perioperative strategy to improve peripheral nerve regeneration and enhance functional recovery. Despite decades of research, new insights into the complex multifaceted mechanisms of electrical stimulation continue to emerge, providing greater understanding of the neurophysiology of nerve regeneration. In this study, we summarize what is known about how electrical stimulation modulates the molecular cascades and cellular responses innate to nerve injury and repair, and the consequential effects on axonal growth and plasticity. Further, we discuss how electrical stimulation is delivered in preclinical and clinical studies and identify knowledge gaps that may provide opportunities for optimization. Competing Interests: Disclosure J.L. Senger has nothing to declare. H. Power has nothing to declare. A.M. Moore: Checkpoint Surgical, Inc. Educator, Research Collaborator and Consultant. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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