Immunomodulation and fibroblast dynamics driving nociceptive joint pain within inflammatory synovium: Unravelling mechanisms for therapeutic advancements in osteoarthritis.

Autor: Wijesinghe SN; Institute of Inflammation and Ageing, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: s.n.wijesinghe@bham.ac.uk., Ditchfield C; Institute of Inflammation and Ageing, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: c.ditchfield@bham.ac.uk., Flynn S; Institute of Inflammation and Ageing, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: sxf896@student.bham.ac.uk., Agrawal J; School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK. Electronic address: Jyoti.Agrawal@nottingham.ac.uk., Davis ET; The Royal Orthopaedic Hospital, Birmingham B31 2AP, UK. Electronic address: Edward.davis@bhs.net., Dajas-Bailador F; School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK. Electronic address: F.Dajas-Bailador@nottingham.ac.uk., Chapman V; Pain Centre Versus Arthritis, NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, UK. Electronic address: victoria.chapman@nottingham.ac.uk., Jones SW; Institute of Inflammation and Ageing, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham B15 2TT, UK. Electronic address: s.w.jones@bham.ac.uk.
Jazyk: angličtina
Zdroj: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2024 Nov; Vol. 32 (11), pp. 1358-1370. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1016/j.joca.2024.06.011
Abstrakt: Objective: Synovitis is a widely accepted sign of osteoarthritis (OA), characterised by tissue hyperplasia, where increased infiltration of immune cells and proliferation of resident fibroblasts adopt a pro-inflammatory phenotype, and increased the production of pro-inflammatory mediators that are capable of sensitising and activating sensory nociceptors, which innervate the joint tissues. As such, it is important to understand the cellular composition of synovium and their involvement in pain sensitisation to better inform the development of effective analgesics.
Methods: Studies investigating pain sensitisation in OA with a focus on immune cells and fibroblasts were identified using PubMed, Web of Science and SCOPUS.
Results: In this review, we comprehensively assess the evidence that cellular crosstalk between resident immune cells or synovial fibroblasts with joint nociceptors in inflamed OA synovium contributes to peripheral pain sensitisation. Moreover, we explore whether the elucidation of common mechanisms identified in similar joint conditions may inform the development of more effective analgesics specifically targeting OA joint pain.
Conclusion: The concept of local environment and cellular crosstalk within the inflammatory synovium as a driver of nociceptive joint pain presents a compelling opportunity for future research and therapeutic advancements.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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