Mortality in sea lions is associated with the introduction of the H5N1 clade 2.3.4.4b virus in Brazil October 2023: whole genome sequencing and phylogenetic analysis.

Autor: de Carvalho Araujo A; Department of Veterinary Medicine, FZEA- USP, University of São Paulo, 225 Av Duque de Caxias Norte, Pirassununga, SP, 13635900, Brazil., Cho AY; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea., Silva LMN; Graduate Program in Experimental Epidemiology Applied to Zoonoses, Veterinary Medicine and Animal Science School, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Butantã, São Paulo, SP, 05508270, Brazil., Corrêa TC; Department of Veterinary Medicine, FZEA- USP, University of São Paulo, 225 Av Duque de Caxias Norte, Pirassununga, SP, 13635900, Brazil., de Souza GC; Zoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil., Albuquerque AS; Zoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil., Macagnan E; Zoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil., Kolesnikvoas CKM; R3 Animal Association, Rod. João Gualberto Soares 11.000, Florianópolis, SC, 88060-000, Brazil., Meurer R; R3 Animal Association, Rod. João Gualberto Soares 11.000, Florianópolis, SC, 88060-000, Brazil., Vieira JV; Marine Tetrapod Ecology and Conservation Laboratory, Marine Animal Stabilization Unit, São Francisco do Sul, University of the Joinville Region, UNIVILLE, Rod. Duque de Caxias 6.365, São Francisco do Sul, SC, 89240-000, Brazil., Lemos GG; Marine Tetrapod Ecology and Conservation Laboratory, Marine Animal Stabilization Unit, São Francisco do Sul, University of the Joinville Region, UNIVILLE, Rod. Duque de Caxias 6.365, São Francisco do Sul, SC, 89240-000, Brazil., Barreto AS; LIBGeo, UNIVALI, Rua Uruguai 458, Itajaí, SC, 88301-902, Brazil., Dick JL; Marine Animal Stabilization Unit, University of Vale do Itajaí - Univali BR, R Maria Emilia, 90, Armação, Penha, SC, 88385-000, Brazil., Groch KR; Australis Institute, Av. Atlantica, Sn, Praia de Itapirubá Norte, Imbituba, SC, 88780-000, Brazil., de Castilho PV; Zoology Laboratory, Stabilization Unit, Laguna, UDESC, Av. Colombo Machado Salles 1873, Laguna, SC, 88790-000, Brazil., Amgarten D; Albert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil., Malta F; Albert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil., Miller M; BSL-3 Laboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas - UNICAMP, P.O.Box: 6109, Campinas, SP, 13083-862, Brazil., Dorlass EG; Albert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil., Palameta S; BSL-3 Laboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas - UNICAMP, P.O.Box: 6109, Campinas, SP, 13083-862, Brazil., Lee SH; Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea., Arns CW; BSL-3 Laboratory of Virology and Applied Biotechnology, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas - UNICAMP, P.O.Box: 6109, Campinas, SP, 13083-862, Brazil., Durigon EL; BSL3+ Laboratory of Clinical and Molecular Virology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1374, São Paulo, SP, 05508-000, Brazil.; Pasteur Institute of São Paulo/USP, University of São Paulo, São Paulo, 05508-020, Brazil., Pinho JRR; Albert Einstein Israelite Hospital, Av. Albert Einstein, 627/701, São Paulo, SP, 05652-900, Brazil.; LIM03/07, Institute of Tropical Medicine and Clinics Hospital, University of São Paulo School of Medicine, São Paulo, 05403-000, Brazil., Lee DH; Wildlife Health Laboratory, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea.; Konkuk University Zoonotic Diseases Research Center, College of Veterinary Medicine, Konkuk University, 120 Neungdong-Ro, Gwangjin-Gu, Seoul, 05029, Republic of Korea., Ferreira HL; Department of Veterinary Medicine, FZEA- USP, University of São Paulo, 225 Av Duque de Caxias Norte, Pirassununga, SP, 13635900, Brazil. hlage@usp.br.; Graduate Program in Experimental Epidemiology Applied to Zoonoses, Veterinary Medicine and Animal Science School, University of São Paulo, Av. Prof. Orlando Marques de Paiva, 87, Butantã, São Paulo, SP, 05508270, Brazil. hlage@usp.br.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2024 Jul 02; Vol. 20 (1), pp. 285. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1186/s12917-024-04137-1
Abstrakt: Clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 virus was detected in the South American sea lions found dead in Santa Catarina, Brazil, in October 2023. Whole genome sequencing and comparative phylogenetic analysis were conducted to investigate the origin, genetic diversity, and zoonotic potentials of the H5N1 viruses. The H5N1 viruses belonged to the genotype B3.2 of clade 2.3.4.4b H5N1 virus, which was identified in North America and disseminated to South America. They have acquired new amino acid substitutions related to mammalian host affinity. Our study provides insights into the genetic landscape of HPAI H5N1 viruses in Brazil, highlighting the continuous evolutionary processes contributing to their possible adaptation to mammalian hosts.
(© 2024. The Author(s).)
Databáze: MEDLINE
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