A rapid narrative review of the clinical evolution of psychedelic treatment in clinical trials.

Autor: Kishon R; Department of Psychiatry, Columbia University, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Modlin NL; The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Nadav.modlin@kcl.ac.uk.; South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK. Nadav.modlin@kcl.ac.uk., Cycowicz YM; Department of Psychiatry, Columbia University, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA., Mourtada H; New York State Psychiatric Institute, New York, NY, USA.; Department of Clinical Psychology, Teachers College, Columbia University, New York, NY, USA., Wilson T; New York State Psychiatric Institute, New York, NY, USA., Williamson V; The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Experimental Psychology, Anna Watts Building, University of Oxford, Oxford, UK., Cleare A; The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK., Rucker J; The Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; South London and Maudsley NHS Foundation Trust, Maudsley Hospital, London, UK.
Jazyk: angličtina
Zdroj: Npj mental health research [Npj Ment Health Res] 2024 Jul 02; Vol. 3 (1), pp. 33. Date of Electronic Publication: 2024 Jul 02.
DOI: 10.1038/s44184-024-00068-9
Abstrakt: Pre-prohibition psychedelic research with complex psychiatric patients generated a wealth of treatment methodologies and practices, providing invaluable clinical insights pertaining to the medical administration of psychedelics in various mental health diagnoses. Building upon these early studies, which lack the rigor and research tools available today, contemporary psychedelic research has focused on investigating the safety and efficacy of psychedelics in randomized controlled trials via psychometric measures and symptom assessments. Both then and now, the treatment context and the role of clinicians in psychedelic treatment has been recognized as an essential feature for positive patient outcomes. To broaden the knowledge base of modern psychedelic research and support the training of clinicians conducting medically supervised psychedelic research studies, this paper provides a review of pre-prohibition clinical research narratives pertaining to the phenomenology of psychedelic treatment and the role of the non-pharmacological treatment factors in the patient experience. Lastly, this paper explores a range of clinician perspectives and psychological interventions employed in pre-prohibition psychedelic research to inform future research directions and best practice guidelines.
(© 2024. The Author(s).)
Databáze: MEDLINE
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