Usefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction.
| Autor: | Bulut M; Sultanbeyli State Hospital, Department of Cardiology, Istanbul, Turkey (Dr Bulut)., Celik FB; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan)., Guvenc TS; Istinye University School of Medicine, Department of Cardiology, Istanbul, Turkey (Dr Guvenc)., Yilmaz Y; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan). Electronic address: dr.ysufyilmaz@gmail.com., Celik M; Kartal Kosuyolu Heart and Research Hospital, Department of Cardiology, Istanbul, Turkey (Dr Celik)., Ozyildirim S; Istanbul University-Cerrahpasa, Department of Cardiology, Cardiology Institute, Istanbul, Turkey (Dr Ozyildirim)., Gocer K; Necip Fazil State Hospital, Department of Cardiology, Kahramanmaras, Turkey., Asik M; Istanbul Medeniyet University School of Medicine (Dr Asik), Department of Radiology, Istanbul, Turkey., Kul S; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan)., Caliskan M; Istanbul Medeniyet University School of Medicine, Department of Cardiology, Istanbul, Turkey (Drs Celik, Yilmaz, Kul and Caliskan). |
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| Jazyk: | angličtina |
| Zdroj: | Journal of clinical lipidology [J Clin Lipidol] 2024 Sep-Oct; Vol. 18 (5), pp. e764-e772. Date of Electronic Publication: 2024 May 06. |
| DOI: | 10.1016/j.jacl.2024.04.135 |
| Abstrakt: | Background: Coronary microvascular dysfunction (CMD) is a common occurrence in individuals with insulin resistance (IR). Homeostatic model assessment for insulin resistance (HOMA-IR) is a widely used surrogate marker of IR, although recent studies suggest triglyceride-glucose (TyG) index is a superior marker of IR that had a better accuracy to predict type 2 diabetes or cardiovascular outcomes than HOMA-IR. Objectives: We aimed to assess the accuracy and usefulness of TyG index and HOMA-IR for predicting CMD as assessed with echocardiographic coronary flow reserve (CFR) measurement. Methods: All cases included in the institutional CFR registry were retrospectively reviewed, and 656 cases without epicardial coronary artery disease and without major risk factors for atherosclerosis were included. A CFR ≤2.0 was defined as CMD. Results: TyG index was available in all cases, while HOMA-IR was available in 398 cases. Both TyG index and HOMA-IR were associated with CMD on univariate analyses, while after adjustment for potential confounders HOMA-IR (odds ratio [OR]:1.38, 95% confidence interval [CI]:1.14-1.67, p = 0.001) but not TyG index (OR:1.48, 95% CI:0.82-2.67, p = 0.19) was associated with CMD. The predictive accuracy of HOMA-IR (c-statistic:0.63, 95% CI:0.54-0.72, p = 0.003) was higher than TyG index(c-statistic:0.55, 95% CI:0.47-0.63, p = 0.13), although the difference was not statistically significant (DeLong p = 0.23). There was strong evidence favoring a true difference between CMD vs. non-CMD groups for HOMA-IR (BF Conclusions: HOMA-IR, but not TyG index, is closely associated with CMD. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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