A 2-Year Longitudinal Randomized Control Trial of Speed of Processing Cognitive Training in Aging Adults with HIV-Associated Neurocognitive Disorder: Results of the Think Fast Study.

Autor: Vance DE; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, 35294-1210, USA. devance@uab.edu., Fazeli PL; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, 35294-1210, USA., Azuero A; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, 35294-1210, USA., Frank JS; School of Nursing, University of Alabama at Birmingham, Birmingham, AL, 35294-1210, USA., Wadley VG; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Raper JL; The 1917 (HIV/AIDS) Clinic, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Pope CN; Department of Health, Behavior & Society, University of Kentucky, Lexington, KY, USA., Ball KK; Department of Psychology, UAB, University of Alabama at Birmingham, Birmingham, AL, USA.
Jazyk: angličtina
Zdroj: AIDS and behavior [AIDS Behav] 2024 Oct; Vol. 28 (10), pp. 3300-3314. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1007/s10461-024-04409-9
Abstrakt: Nearly 40% of people with HIV (PWH) experience HIV-associated Neurocognitive Disorder (HAND). In this 3-group efficacy study, 216 PWH 40 + years with HAND or borderline HAND were randomized to either: (1) 10 h of SOP training (n = 70); (2) 20 h of SOP training (n = 73), or (3) 10 h of Internet navigation training (n = 73; contact control group). Participants were administered a measure of SOP [i.e., the Useful Field of View Test (UFOV®)] at baseline, at posttest immediately after training, and at year 1 and year 2 follow up. Intent-to-treat linear mixed-effect models with subject-specific intercept and slope were fitted to estimate between-group mean differences at the follow-up time-points. At the post-intervention time-point, small beneficial SOP training effects were observed for the 10-h group in UFOV® total (d = 0.28, p = 0.002). Effects were of larger magnitude for the 20-h group in these same outcomes [UFOV® total (d = 0.43, p < 0.001)]. These results indicated better benefit with more training. No intervention effect was observed at year 1. At year 2, beneficial effects of small magnitude were observed again in the 10-h group [UFOV® total (d = 0.22, p = 0.253)] with larger small-to-moderate magnitude in the 20-h group [UFOV® total (d = 0.32, p = 0.104)]. This study suggests that SOP training can improve a key indicator of this cognitive performance and that treatment gains are small-to-moderate over a two-year period. Prior literature suggests slower SOP is predictive of impairment in everyday functioning in older PWH; such an approach could potentially improve everyday functioning in PWH.
(© 2024. The Author(s).)
Databáze: MEDLINE
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