Human Olivocochlear Effects: A Statistical Detection Approach Applied to the Cochlear Microphonic Evoked by Swept Tones.

Autor: Goodman SS; Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, USA., Haysley S; Department of Communication Sciences and Disorders, University of Utah, Salt Lake City, UT, USA., Jennings SG; Department of Communication Sciences and Disorders, University of Utah, Salt Lake City, UT, USA. skyler.jennings@hsc.utah.edu.
Jazyk: angličtina
Zdroj: Journal of the Association for Research in Otolaryngology : JARO [J Assoc Res Otolaryngol] 2024 Oct; Vol. 25 (5), pp. 451-475. Date of Electronic Publication: 2024 Jul 01.
DOI: 10.1007/s10162-024-00956-z
Abstrakt: The human medial olivocochlear (MOC) reflex was assessed by observing the effects of contralateral acoustic stimulation (CAS) on the cochlear microphonic (CM) across a range of probe frequencies. A frequency-swept probe tone (125-4757 Hz, 90 dB SPL) was presented in two directions (up sweep and down sweep) to normal-hearing young adults. This study assessed MOC effects on the CM in individual participants using a statistical approach that calculated minimum detectable changes in magnitude and phase based on CM signal-to-noise ratio (SNR). Significant increases in CM magnitude, typically 1-2 dB in size, were observed for most participants from 354 to 1414 Hz, where the size and consistency of these effects depended on participant, probe frequency, sweep direction, and SNR. CAS-related phase lags were also observed, consistent with CM-based MOC studies in laboratory animals. Observed effects on CM magnitude and phase were in the opposite directions of reported effects on otoacoustic emissions (OAEs). OAEs are sensitive to changes in the motility of outer hair cells located near the peak region of the traveling wave, while the effects of CAS on the CM likely originate from MOC-related changes in the conductance of outer hair cells located in the basal tail of the traveling wave. Thus, MOC effects on the CM are complementary to those observed for OAEs.
(© 2024. The Author(s) under exclusive licence to Association for Research in Otolaryngology.)
Databáze: MEDLINE
Externí odkaz: