| Autor: |
Oladele JO; Biochemistry Unit, Department of Chemical Sciences, Kings University, Ode-Omu, Nigeria.; Phytochemistry and Phytomedicine Research Unit, Royal Scientific Research Institute, Osun State, Nigeria., Ojuederie OB; Biotechnology Unit, Department of Biological Sciences, Faculty of Science, Kings University, Ode-Omu, Nigeria., Oladele OT; Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria., Ajayi EIO; Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria., Olaniyan MD; Biochemistry Unit, Department of Chemical Sciences, Kings University, Ode-Omu, Nigeria., Atolagbe OS; Forestry Research Institute of Nigeria, Ibadan, Nigeria., Okoro OE; Internal Medicine Department, Mandeville Regional Hospital, Manchester, Jamaica., Adewale OO; Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria., Oyeleke OM; Biochemistry Unit, Department of Chemical Sciences, Kings University, Ode-Omu, Nigeria. |
| Abstrakt: |
The increase in the incidence of gastric ulcer (GU) has posed major threat on public health. This research aimed to evaluate gastroprotective properties of the aqueous leaf extract of Talium triangulare (AETT) in ethanol-induced gastric ulceration. GU was induced via oral administration of single dose of 5 mLkg -1 of 90% ethanol in rats and protection of 200 mgkg -1 bw of AETT and 20 mgkg -1 bw of omeprazole was investigated for 14 d via oral treatment. Influence of AETT on anti-inflammatory, redox assays, ulcer index (UI), and gastric mucosa histological alterations were evaluated. Significant increase in myeloperoxidase (MPO) and tumor necrosis factor-alpha levels compared to untreated group established gastric inflammation in rats induced by ethanol. Gastric ulcerated group exhibited heightened oxidative stress with concurrent decline in activities of antioxidant enzymes. Ethanol exposure to rats resulted in induction of lipid peroxidation, prominently elevating gastric malondialdehyde (MDA) concentration. Nevertheless, treatment with AETT or omeprazole exhibited substantial anti-inflammatory effects within gastric mucosa by attenuating expression of markers associated with inflammation. AETT demonstrated reduction in concentrations of MDA and H 2 O 2 , thereby alleviating progression of lipid peroxidation cascades. Also, AETT exhibited mitigating effect on ethanol-induced oxidative harm by enhancing the functionality of protective enzymes and elevating glutathione (GSH) concentration. Overall, AETT exhibited enhancements in activities of cytoprotective antioxidant enzymes, mitigated impact of oxidative stress and inflammation, inhibited lipid peroxidation, and decreased UI score. These beneficial effects could be attributed to phytochemicals present in AETT including 6,10,14-trimethyl-2-pentadecanone and Phytol. Outcome of this study established the traditional herbal claims of AETT. |
