| Autor: |
Nguyen TM, Ross MK, Ning E, Kabir S, Cladek AT, Barve A, Kennelly E, Hussain F, Duffecy J, Langenecker SL, Zulueta J, Demos AP, Ajilore OA, Leow AD |
| Jazyk: |
angličtina |
| Zdroj: |
MedRxiv : the preprint server for health sciences [medRxiv] 2024 Jun 13. Date of Electronic Publication: 2024 Jun 13. |
| DOI: |
10.1101/2024.06.12.24308834 |
| Abstrakt: |
Impulsivity can be a risk factor for serious complications for those with mood disorders. To understand intra-individual impulsivity variability, we analyzed longitudinal data of a novel gamified digital Go/No-Go (GNG) task in a clinical sample (n=43 mood disorder participants, n=17 healthy controls) and an open-science sample (n=121, self-reported diagnoses). With repeated measurements within-subject, we disentangled two aspects of GNG: reaction time and accuracy in response inhibition (i.e., incorrect No-Go trials) with respect to diurnal and potential learning effects. Mixed-effects models showed diurnal effects in reaction time but not accuracy, with a significant effect of hour on reaction time in the clinical sample and the open-science sample. Moreover, subjects improved on their response inhibition but not reaction time. Additionally, significant interactions emerged between depression symptom severity and time-of-day in both samples, supporting that repeated administration of our GNG task can yield mood-dependent circadian rhythm-aware biomarkers of neurocognitive function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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