Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients.

Autor: Nguyen Duy T; Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Hanoi, 10000, Viet Nam., Le Huy H; Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, 10000, Viet Nam., Đao Thanh Q; Vietnamese-German Center of Medical Research (VG-CARE), 108 Military Central Hospital, Hanoi, 100000, Viet Nam., Ngo Thi H; Department of Gastroenterological Intensive Care, 108 Military Central Hospital, Hanoi, 10000, Viet Nam., Ngo Thi Minh H; Department of Pathology, 108 Military Central Hospital, Hanoi, 10000, Viet Nam., Nguyen Dang M; Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Hanoi, 10000, Viet Nam., Le Huu S; Institute of Clinical Infectious Diseases, 108 Military Central Hospital, Hanoi, 10000, Viet Nam; Vietnamese-German Center of Medical Research (VG-CARE), 108 Military Central Hospital, Hanoi, 100000, Viet Nam. Electronic address: lehuusong@108-icid.com., Ngo Tat T; Vietnamese-German Center of Medical Research (VG-CARE), 108 Military Central Hospital, Hanoi, 100000, Viet Nam; Centre for Genetics Consultation and Cancer Screening, 108 Military Central Hospital, Hanoi, 100000, Viet Nam. Electronic address: tatrungngo@gmail.com.
Jazyk: angličtina
Zdroj: Anaerobe [Anaerobe] 2024 Aug; Vol. 88, pp. 102880. Date of Electronic Publication: 2024 Jun 26.
DOI: 10.1016/j.anaerobe.2024.102880
Abstrakt: Background: Colorectal cancer (CRC) is a significant global health concern, and understanding the role of specific bacterial infections in its development and progression is of increasing interest. This cross-sectional study investigated the associations between Bacteroides fragilis (B. fragilis) and Fusobacterium nucleatum (F. nucleatum) infections and Vietnamese CRC patients.
Methods: 192 patients with either polyps or CRC at varying stages were recruited from May 2017 to December 2020. Real-time PCR assessed infection rates and bacterial loads in CRC tissues.
Results: B. fragilis infection was notably higher in CRC tissues (51.6 %) than polyps (9.4 %), with a fivefold higher relative load. Positive associations were found in stages II and III, indicating a fivefold increase in CRC progression risk. F. nucleatum infection rates were significantly higher in CRC tissues (55.2 %) than in polyps (10.5 %). In stage II, the infection rate exceeded that in adjacent tissues. The relative load of F. nucleatum was higher in stage III than in stages I and II. Positive F. nucleatum patients had a 3.2 times higher risk of CRC progression.
Conclusion: These findings suggest associations between loading of F. nucleatum or/and B. fragilis with the advanced stages of CRC.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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