A novel titanium alloy for load-bearing biomedical implants: Evaluating the antibacterial and biocompatibility of Ti536 produced via electron beam powder bed fusion additive manufacturing process.

Autor: Behjat A; Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Integrated Additive Manufacturing Center, Department of Management and Production Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy., Sanaei S; Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran., Mosallanejad MH; Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran; Integrated Additive Manufacturing Center, Department of Management and Production Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy., Atapour M; Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran. Electronic address: M.atapour@cc.iut.ac.ir., Sheikholeslam M; Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran., Saboori A; Integrated Additive Manufacturing Center, Department of Management and Production Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy. Electronic address: Abdollah.saboori@polito.it., Iuliano L; Integrated Additive Manufacturing Center, Department of Management and Production Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Jazyk: angličtina
Zdroj: Biomaterials advances [Biomater Adv] 2024 Oct; Vol. 163, pp. 213928. Date of Electronic Publication: 2024 Jun 18.
DOI: 10.1016/j.bioadv.2024.213928
Abstrakt: Additive manufacturing (AM) of Ti-based biomedical implants is a pivotal research topic because of its ability to produce implants with complicated geometries. Despite desirable mechanical properties and biocompatibility of Ti alloys, one major drawback is their lack of inherent antibacterial properties, increasing the risk of postoperative infections. Hence, this research focuses on the Ti536 (Ti5Al3V6Cu) alloy, developed through Electron Beam Powder Bed Fusion (EB-PBF), exploring bio-corrosion, antibacterial features, and cell biocompatibility. The microstructural characterization revealed grain refinement and the formation of Ti 2 Cu precipitates with different morphologies and sizes in the Ti matrix. Electrochemical tests showed that Cu content minimally influenced the corrosion current density, while it slightly affected the stability, defect density, and chemical composition of the passive film. According to the findings, the Ti536 alloy demonstrated enhanced antibacterial properties without compromising its cell biocompatibility and corrosion behavior, thanks to Ti 2 Cu precipitates. This can be attributed to both the release of Cu ions and the Ti 2 Cu precipitates. The current study suggests that the EB-PBF fabricated Ti536 sample is well-suited for use in load-bearing applications within the medical industry. This research also offers an alloy design roadmap for novel biomedical Ti-based alloys with superior biological performance using AM methods.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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