Integration of Electrospun Scaffolds and Biological Polymers for Enhancing the Delivery and Efficacy of Mesenchymal Stem/Stromal Cell Therapies.

Autor:	Barcena AJR; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; College of Medicine, University of the Philippines Manila, 1000 Manila, Philippines., Mishra A; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Bolinas DKM; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; College of Medicine, University of the Philippines Manila, 1000 Manila, Philippines., Martin BM; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Baylor College of Medicine, Houston, TX 77030, USA., Melancon MP; Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Jazyk:	angličtina
Zdroj:	Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Jun 24; Vol. 29 (6), pp. 228.
DOI:	10.31083/j.fbl2906228
Abstrakt:	Mesenchymal stem/stromal cells (MSCs) have emerged as a promising therapeutic approach for a variety of diseases due to their immunomodulatory and tissue regeneration capabilities. Despite their potential, the clinical application of MSC therapies is hindered by limited cell retention and engraftment at the target sites. Electrospun scaffolds, with their high surface area-to-volume ratio and tunable physicochemical properties, can be used as platforms for MSC delivery. However, synthetic polymers often lack the bioactive cues necessary for optimal cell-scaffold interactions. Integrating electrospun scaffolds and biological polymers, such as polysaccharides, proteins, and composites, combines the mechanical integrity of synthetic materials with the bioactivity of natural polymers and represents a strategic approach to enhance cell-scaffold interactions. The molecular interactions between MSCs and blended or functionalized scaffolds have been examined in recent studies, and it has been shown that integration can enhance MSC adhesion, proliferation, and paracrine secretion through the activation of multiple signaling pathways, such as FAK/Src, MAPK, PI3K/Akt, Wnt/β-catenin, and YAP/TAZ. Preclinical studies on small animals also reveal that the integration of electrospun scaffolds and natural polymers represents a promising approach to enhancing the delivery and efficacy of MSCs in the context of regenerating bone, cartilage, muscle, cardiac, vascular, and nervous tissues. Future research should concentrate on identifying the distinct characteristics of the MSC niche, investigating the processes involved in MSC-scaffold interactions, and applying new technologies in stem cell treatment and biofabrication to enhance scaffold design. Research on large animal models and collaboration among materials scientists, engineers, and physicians are crucial to translating these advancements into clinical use. Competing Interests: The authors declare no conflict of interest. (© 2024 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
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