Lanthanum nitrate demonstrated no genotoxicity in the conducted tests.

Autor: Juntao L; Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, China., Wenxue L; Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, China., Guangyu Y; Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, China., Xudong L; Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China., Runxuan Z; Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China., Bo Z; Food Safety and Health Research Center, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: zhangbo2018@smu.edu.cn., Wei Z; Department of Toxicology, Guangzhou Center for Disease Control and Prevention, Guangzhou, China. Electronic address: gzcdc_zhuw@gz.gov.cn.
Jazyk: angličtina
Zdroj: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2024 Aug; Vol. 151, pp. 105670. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1016/j.yrtph.2024.105670
Abstrakt: Given the widespread applications in industrial and agricultural production, the health effects of rare earth elements (REEs) have garnered public attention, and the genotoxicity of REEs remains unclear. In this study, we evaluated the genetic effects of lanthanum nitrate, a typical representative of REEs, with guideline-compliant in vivo and in vitro methods. Genotoxicity assays, including the Ames test, comet assay, mice bone marrow erythrocyte micronucleus test, spermatogonial chromosomal aberration test, and sperm malformation assay were conducted to assess mutagenicity, chromosomal damage, DNA damage, and sperm malformation. In the Ames test, no statistically significant increase in bacterial reverse mutation frequencies was found as compared with the negative control. Mice exposed to lanthanum nitrate did not exhibit a statistically significant increase in bone marrow erythrocyte micronucleus frequencies, spermatogonial chromosomal aberration frequencies, or sperm malformation frequencies compared to the negative control (P > 0.05). Additionally, after a 24-h treatment with lanthanum nitrate at concentrations of 1.25, 5, and 20 μg/ml, no cytotoxicity was observed in CHL cells. Furthermore, the comet assay results indicate no significant DNA damage was observed even after exposure to high doses of lanthanum nitrate (20 μg/ml). In conclusion, our findings suggest that lanthanum nitrate does not exhibit genotoxicity.
Competing Interests: Declaration of Competing interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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