Grading differentiation in cutaneous squamous cell carcinoma: a review of the literature.

Autor: Diede C; University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA., Walker T; The Ohio State University College of Medicine, Columbus, OH, USA., Carr DR; Department of Dermatology, The Ohio State University Medical Center, 6700 University Blvd, Columbus, OH, 43016, USA., Shahwan KT; University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA. Kathryn.Shahwan@osumc.edu.; Department of Dermatology, The Ohio State University Medical Center, 6700 University Blvd, Columbus, OH, 43016, USA. Kathryn.Shahwan@osumc.edu.; Department of Dermatology, Altru Health System, Grand Forks, Grand Forks, ND, USA. Kathryn.Shahwan@osumc.edu.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Jun 27; Vol. 316 (7), pp. 434. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1007/s00403-024-03184-w
Abstrakt: Poor differentiation is strongly associated with poor outcomes in cutaneous squamous cell carcinoma (CSCC). In addition, the National Comprehensive Cancer Network (NCCN) guidelines designate poorly differentiated tumors as "very high risk". Despite its clear prognostic implications, there is no standardized grading system for CSCC differentiation in common use today. CSCC differentiation is graded inconsistently by both dermatopathologists and Mohs surgeons, and reliability studies have demonstrated suboptimal inter- and intra-rater reliability in both of these groups. The absence of a standardized and reliable grading system has impeded the use of differentiation in CSCC staging, despite its apparent correlation with disease outcomes. We performed a comprehensive review of the literature summarizing historical CSCC differentiation grading systems, as well as grading systems in non-cutaneous head and neck SCC as a point of reference. Relevant articles were identified by searching Embase and PubMed, as well as by reviewing reference lists for additional articles and histology textbook excerpts. CSCC grading systems that were identified and summarized include the historical Broders system, the World Health Organization system, the College of American Pathologists' system, and a system described by a 2023 Delphi consensus panel of dermatopathologists.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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