| Autor: |
Oalđe Pavlović M; University of Belgrade-Faculty of Biology, Institute of Botany and Botanical Garden 'Jevremovac', Studentski Trg 16, 11000 Belgrade, Serbia., Kolarević S; University of Belgrade-Institute for Biological Research 'Siniša Stanković', National Institute of the Republic of Serbia, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia., Đorđević Aleksić J; University of Belgrade-Institute for Multidisciplinary Research, Kneza Višeslava 1, 11000 Belgrade, Serbia., Vuković-Gačić B; University of Belgrade-Faculty of Biology, Institute of Botany and Botanical Garden 'Jevremovac', Studentski Trg 16, 11000 Belgrade, Serbia. |
| Jazyk: |
angličtina |
| Zdroj: |
Plants (Basel, Switzerland) [Plants (Basel)] 2024 Jun 11; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 11. |
| DOI: |
10.3390/plants13121616 |
| Abstrakt: |
In response to the global rise in antibiotic resistance and the prevalence of bacterial biofilm-related infections, the antibacterial efficacy of methanolic, ethanolic, and aqueous extracts of 18 Lamiaceae plants from Serbia was evaluated. The total coumarins and triterpenes were detected spectrophotometrically, while a microdilution assay measured their effects on bacterial growth. Additionally, the impact of these extracts was assessed on Pseudomonas aeruginosa PAO1 adhesion and invasion in human fibroblasts and biofilm formation and degradation. The alcoholic extracts had the highest phytochemical content, with Teucrium montanum and Lavandula angustifolia being the richest in coumarins and triterpenes, respectively. Gram-positive bacteria, particularly Bacillus subtilis , were more susceptible to the extracts. Hyssopus officinalis ethanolic and Sideritis scardica methanolic extracts inhibited bacterial growth the most efficiently. Although the extracts did not inhibit bacterial adhesion, most ethanolic extracts significantly reduced bacterial invasion. Origanum vulgare and H. officinalis ethanolic extracts significantly inhibited biofilm formation, while Teucrium chamaedrys extract was the most active in biofilm degradation. This study significantly contributes to the literature by examining the antibacterial activity of Lamiaceae extracts, addressing major literature gaps, and underscoring their antibacterial potential, particularly Satureja montana and O. vulgare ethanolic extracts, linking their efficacy to coumarins and triterpenes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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