Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer.

Autor: Jackson JC; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sanchez D; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Johns AC; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Campbell MT; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Aydin AM; Division of Urology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Gokden N; Division of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Maraboyina S; Division of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Muesse JL; Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA., Ward JF; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Pisters LL; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Zacharias NM; Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Guo CC; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Tu SM; Division of Hematology/Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Jun 12; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 12.
DOI: 10.3390/jcm13123436
Abstrakt: Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate.
Databáze: MEDLINE
Nepřihlášeným uživatelům se plný text nezobrazuje