| Autor: |
Leung HKM; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China., Lo EKK; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China., Zhang F; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China., Felicianna; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China., Ismaiah MJ; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China., Chen C; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China., El-Nezami H; School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR 999077, China.; Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland. |
| Abstrakt: |
Cancers are causing millions of deaths and leaving a huge clinical and economic burden. High costs of cancer drugs are limiting their access to the growing number of cancer cases. The development of more affordable alternative therapy could reach more patients. As gut microbiota plays a significant role in the development and treatment of cancer, microbiome-targeted therapy has gained more attention in recent years. Dietary and natural compounds can modulate gut microbiota composition while providing broader and more accessible access to medicine. Tea compounds have been shown to have anti-cancer properties as well as modulate the gut microbiota and their related metabolites. However, there is no comprehensive review that focuses on the gut modulatory effects of tea compounds and their impact on reshaping the metabolic profiles, particularly in cancer models. In this review, the effects of different tea compounds on gut microbiota in cancer settings are discussed. Furthermore, the relationship between these modulated bacteria and their related metabolites, along with the mechanisms of how these changes led to cancer intervention are summarized. |
