| Autor: |
Egorov V; Ilyinskaya Hospital, 143421 Moscow, Russia.; Burnasyan State Research Center of the Federal Medical Biological Agency, 119435 Moscow, Russia., Kim P; Ilyinskaya Hospital, 143421 Moscow, Russia., Dzigasov S; Ilyinskaya Hospital, 143421 Moscow, Russia., Kondratiev E; Ilyinskaya Hospital, 143421 Moscow, Russia.; Radiology Department, Vishnevsky National Medical Research Center of Surgery, 117997 Moscow, Russia., Sorokin A; Department of Mathematical Methods in Economics, Plekhanov Russian University of Economics, 117997 Moscow, Russia., Kolygin A; Ilyinskaya Hospital, 143421 Moscow, Russia., Vyborniy M; Ilyinskaya Hospital, 143421 Moscow, Russia., Bolshakov G; Ilyinskaya Hospital, 143421 Moscow, Russia., Popov P; Ilyinskaya Hospital, 143421 Moscow, Russia., Demchenkova A; Ilyinskaya Hospital, 143421 Moscow, Russia., Dakhtler T; Ilyinskaya Hospital, 143421 Moscow, Russia. |
| Abstrakt: |
The "vein definition" for locally advanced pancreatic ductal adenocarcinoma (LA PDAC) assumes portal-to-superior mesenteric vein (PV/SMV) unreconstructability due to tumor involvement or occlusion. Radical pancreatectomies with SMV resection without PV/SMV reconstruction are scarcely discussed in the literature. Retrospective analysis of 19 radical pancreatectomies for "low" LA PDAC with SMV and all its tributaries resection without PV/SMV reconstruction has shown zero mortality; overall morbidity-56%; Dindo-Clavien-3-10.5%; R0-rate-82%; mean operative procedure time-355 ± 154 min; mean blood loss-330 ± 170 mL; delayed gastric emptying-25%; and clinically relevant postoperative pancreatic fistula-8%. In three cases, surgery was associated with superior mesenteric (n2) and common hepatic artery (n1) resection. Surgery was completed without vein reconstruction (n13) and with inferior mesenteric-to-splenic anastomosis (n6). There were no cases of liver, gastric, or intestinal ischemia. A specific complication of the SMV resection without reconstruction was 2-3 days-long intestinal edema (48%). Median overall survival was 25 months, and median progression-free survival was 18 months. All the relapses, except two, were distant. The possibility of successful SMV resection without PV/SMV reconstruction can be predicted before surgery by CT-based reconstructions. The mandatory anatomical conditions for the procedure were as follows: (1) preserved SMV-SV confluence; (2) occluded SMV for any reason (tumor or thrombus); (3) well-developed inferior mesenteric vein collaterals with dilated intestinal veins; (4) no right-sided vein collaterals; and (5) no varices in the upper abdomen. Conclusion: "Low" LA PDACs involving SMV with all its tributaries can be radically and safely resected in highly and specifically selected cases without PV/SMV reconstruction with an acceptable survival rate. |
