| Autor: |
Sanusi KO; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University Sokoto, Sokoto P.M.B. 2346, Nigeria.; Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Sokoto P.M.B. 2346, Nigeria.; Department of Human Physiology, Faculty of Health Sciences, Al-Hikmah University, Ilorin P.M.B. 1601, Nigeria., Ibrahim KG; Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, P.O. Box 2000, Zarqa 13110, Jordan., Abubakar MB; Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman., Shinkafi TS; Department of Biochemistry and Molecular Biology, Faculty of Chemical and Life Sciences, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Sokoto P.M.B. 2346, Nigeria.; Department of Biochemistry, Kampala International University, Western Campus, Bushenyi P.O. Box 71, Uganda., Ishaka A; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Sokoto P.M.B. 2346, Nigeria.; Department of Medical Biochemistry, Faculty of Basic Medial Sciences, College of Health Sciences, Nile University of Nigeria, Abuja F.C.T. 900108, Nigeria., Imam MU; Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University Sokoto, Sokoto P.M.B. 2346, Nigeria.; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University Sokoto, Sokoto P.M.B. 2346, Nigeria. |
| Abstrakt: |
Zinc deficiency is a common nutritional disorder with detrimental health consequences. Whether parental zinc deficiency induces intergenerational effects remains largely unknown. We investigated the effects of a combined maternal and paternal zinc deficiency on offspring's metabolic outcomes and gene expression changes in Drosophila melanogaster . The parent flies were raised on zinc-deficient diets throughout development, and their progeny were assessed. Offspring from zinc-deprived parents exhibited a significant ( p < 0.05) increase in body weight and whole-body zinc levels. They also displayed disrupted glucose metabolism, altered lipid homeostasis, and diminished activity of antioxidant enzymes. Gene expression analysis revealed significant ( p < 0.05) alterations in zinc transport genes, with increases in mRNA levels of dZIP1 and dZnT1 for female and male offspring, respectively. Both sexes exhibited reduced dZnT35C mRNA levels and significant ( p < 0.05) increases in the mRNA levels of DILP2 and proinflammatory markers, Eiger and UPD2. Overall, female offspring showed higher sensitivity to parental zinc deficiency. Our findings underscore zinc's crucial role in maintaining health and the gender-specific responses to zinc deficiency. There is the need for further exploration of the underlying mechanisms behind these intergenerational effects. |
