Recompensation of cirrhosis in candidates of transplant: Tips and tricks for delisting.
| Autor: | Tonon M; Unit of Internal Medicine and Hepatology, Department of Medicine-DIMED, University and Hospital of Padova, Padova, Italy., Gagliardi R, Zeni N, Piano S |
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| Jazyk: | angličtina |
| Zdroj: | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2024 Nov 01; Vol. 30 (11), pp. 1181-1187. Date of Electronic Publication: 2024 May 28. |
| DOI: | 10.1097/LVT.0000000000000409 |
| Abstrakt: | Liver transplantation (LT) is the most successful treatment for patients with decompensated cirrhosis. The availability of effective and safe etiological treatments has altered the natural history of decompensated cirrhosis. Recently, the concept of recompensation has been defined. Patients who achieve recompensation may be removed from the waiting list for LT. Therefore, achieving an etiological cure is the cornerstone in the treatment of patients with decompensated cirrhosis. However, most patients improve their liver function after an etiologic cure, and only a proportion of patients achieve true recompensation after an etiological cure. Some patients maintain a condition of "MELD purgatory," that is, an improvement in the Model for End-Stage Liver Disease score without relevant clinical improvement that prevents delisting and may be even detrimental because lower Model for End-Stage Liver Disease score delays LT. Herein, we review the available evidence regarding recompensation and the management of recompensated patients on the waiting list for LT. (Copyright © 2024 American Association for the Study of Liver Diseases.) |
| Databáze: | MEDLINE |
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