Heart rate vARiability and physical activity in inpatient treatMent of burnOut and DepressIon (HARMODI): protocol of a cross-sectional study with up to 8-week follow up.

Autor:	Turner W; Division of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.; Clinica Holistica Engiadina SA, Susch, Switzerland., Brühl A; Department of Psychiatry, University Psychiatric Clinics Basel, Basel, Switzerland., Böker H; Department of Psychiatric Research, Psychiatric University Hospital Zurich, Zurich, Switzerland., Schulze B; Schulze Resource Consulting, Genève, Switzerland., Marschall K; Bewegung ist Leben, Klosters, Switzerland., La Marca R; Clinica Holistica Engiadina SA, Susch, Switzerland., Pfaff M; Medical Practice Seegarten, Zürich, Switzerland., Russmann T; Clinica Holistica Engiadina SA, Susch, Switzerland., Schmidt-Trucksäss A; Division of Sport and Exercise Medicine, Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland arno.schmidt-trucksaess@unibas.ch.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2024 Jun 25; Vol. 14 (6), pp. e081299. Date of Electronic Publication: 2024 Jun 25.
DOI:	10.1136/bmjopen-2023-081299
Abstrakt:	Introduction: Chronic stress can cause an imbalance within the autonomic nervous system, thereby affecting cardiovascular and mental health. Physical activity (PA) may have a positive effect on the autonomic nervous system and stress-related disorders, such as depression and burnout. Heart rate variability (HRV) is a non-invasive marker of the autonomic nervous system. However, limited and inconsistent data exist on the exact relationship between HRV, PA and depression and burnout symptoms. The HARMODI study aims to explore whether HRV is a feasible marker of depression and burnout symptoms and aims to evaluate the role of PA in the treatment of stress-related disorders. Methods and Analyses: This is an observational study with a cross-sectional up to 8 week follow-up study design. A total of 153 patients, undergoing psychiatric inpatient treatment with burnout syndrome (Z73) and depressive episode (F32 or F33) or adjustment disorder (F43.2), will be recruited. Data on depression and burnout symptoms, HRV recordings (24-hour, supine, standing and exercise stress test), cognitive function, cardiorespiratory fitness, cardiovascular health, balance and strength will be collected at baseline (T1) and after up to 8 weeks (T2). Continuous data on PA and Ecological Momentary Assessments of exhaustion, mood and tension will be monitored daily throughout inpatient treatment. Multiple regression models, adjusted for potential confounders, will assess the association between HRV as the primary outcome, PA and depression and burnout severity score. Ethics and Dissemination: The protocol has been approved by Swiss Ethics Committee, Cantonal Ethics Committee Zürich. Results of HARMODI will be disseminated through peer-reviewed journals and conference presentations. Trial Registration Number: NCT05874856. Competing Interests: Competing interests: WT is funded through an industry-sponsored PhD by the Clinica Holistica Engiadina and represents the role of the investigator at site. Clinica Holistica Engiadina employed Dr MP (until 30 June 2023) and KM (until 1 January 2024). Clinica Holistica Engiadina also employs Dr TR (since 1 July 2023) and Dr RLM. Professor AS-T, Professor HB and Dr BS are members of the scientific advisory board of the Clinica Holistica Engiadina. Other conflicts of interest are not declared. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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