The association between early regulatory problems and adult peer relationship quality is mediated by the brain's allostatic-interoceptive system.

Autor: Zorjan S; Department of Psychology, Faculty of Arts, University of Maribor, Maribor, Slovenia., Wolke D; Department of Psychology, University of Warwick, Coventry, UK.; Warwick Medical School, University of Warwick, Coventry, UK., Baumann N; Department of Psychology, University of Warwick, Coventry, UK.; Department of Population Health Sciences, University of Leicester, Leicester, UK.; Turner Institute for Brain and Mental Health, School of Psychology Sciences, Monash University, Melbourne, Vic., Australia., Sorg C; Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; TUM-NIC Neuroimaging Center, Technical University of Munich, Munich, Germany., Mulej Bratec S; Department of Psychology, Faculty of Arts, University of Maribor, Maribor, Slovenia.; Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Jazyk: angličtina
Zdroj: Journal of child psychology and psychiatry, and allied disciplines [J Child Psychol Psychiatry] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1111/jcpp.14033
Abstrakt: Background: Early regulatory problems (RPs), i.e., problems with crying, sleeping, and/or feeding during the first years, increase the risk for avoidant personality traits in adulthood, associated with social withdrawal and anxiety. Even more, RPs are linked with functional alterations in the adult default mode and salience networks, comprising the brain's allostatic-interoceptive system (AIS) and playing a role in social interactions. We investigated whether RPs assessed in infancy are associated with difficulties in adult peer relationships mediated by functional alterations of the AIS.
Methods: As part of a large case-controlled prospective study, 42 adults with previous RPs and 70 matched controls (mean age = 28.48, SD = 2.65, 51% male) underwent fMRI during rest. The analysis focused on the intrinsic functional connectivity (iFC) of key nodes of the AIS. Peer relationship quality was assessed via a semi-structured Life Course Interview and the YASR scale. In these same individuals, RPs were assessed at ages 5, 20 and 56 months.
Results: RPs in infancy were associated with lower-quality peer relationships and enhanced functional connectivity of the AIS nodes in adulthood, with a stronger effect for multiple and persistent RPs compared with transient-multiple or single-persistent RPs. Importantly, iFC changes of the dorsal mid insula, a primary interoceptive cortex with frontal and temporal regions, mediated the relationship between early RPs and adult peer relationship quality.
Conclusions: Results indicate long-lasting social and neural changes associated with early RPs. Our findings further implicate the AIS in both interoceptive and social processes, while indicating the need for early screening of early RPs.
(© 2024 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.)
Databáze: MEDLINE
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