Nuclear proteins and diabetic retinopathy: a review.

Autor: Li B; Department of Ophthalmology, The First Affiliated Hospital, Henan University, Kaifeng, 475004, Henan, China., Hussain W; School of Stomatology, Henan University, Kaifeng, 475000, China.; Kaifeng Municipal Key Laboratory for Infection and Biosafety, Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medicine Science, Henan University, Kaifeng, 475000, China., Jiang ZL; School of Clinical Medicine, Henan University, Kaifeng, 475004, Henan, China., Wang JY; San-Quan College, XinXiang Medical University, No. 688 Xiangyang Road, Hongmen Town, Hongqi District, Xinxiang City, Henan, 453003, China., Hussain S; College of Environment, Hohai University, Nanjing, 210098, China., Yasoob TB; Department of Animal Sciences, Ghazi University, Dera Ghazi Khan, 32200, Pakistan., Zhai YK; School of Stomatology, Henan University, Kaifeng, 475000, China. zhaiyuankun@henu.edu.cn.; Kaifeng Key Laboratory of Periodontal Tissue Engineering, Kaifeng, 475000, China. zhaiyuankun@henu.edu.cn., Ji XY; Kaifeng Municipal Key Laboratory for Infection and Biosafety, Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medicine Science, Henan University, Kaifeng, 475000, China. 10190096@vip.henu.edu.cn.; Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Mazhai, Erqi District, Zhengzhou, 450064, Henan, China. 10190096@vip.henu.edu.cn., Dang YL; Department of Ophthalmology, Sanmenxia Central Hospital, Henan University of Science and Technology, Sanmenxia, Henan, China. dangyalong@126.com.; Department of Ophthalmology, Sanmenxia Eye Hospital, Sanmenxia, Henan, China. dangyalong@126.com.; Department of Ophthalmology, Henan University of Science and Technology School of Medicine, Luoyang, Henan, China. dangyalong@126.com.
Jazyk: angličtina
Zdroj: Biomedical engineering online [Biomed Eng Online] 2024 Jun 25; Vol. 23 (1), pp. 62. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1186/s12938-024-01258-4
Abstrakt: Diabetic retinopathy (DR) is an eye disease that causes blindness and vision loss in diabetic. Risk factors for DR include high blood glucose levels and some environmental factors. The pathogenesis is based on inflammation caused by interferon and other nuclear proteins. This review article provides an overview of DR and discusses the role of nuclear proteins in the pathogenesis of the disease. Some core proteins such as MAPK, transcription co-factors, transcription co-activators, and others are part of this review. In addition, some current advanced treatment resulting from the role of nuclear proteins will be analyzes, including epigenetic modifications, the use of methylation, acetylation, and histone modifications. Stem cell technology and the use of nanobiotechnology are proposed as promising approaches for a more effective treatment of DR.
(© 2024. The Author(s).)
Databáze: MEDLINE
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