Comparison of Individual Regimen Containing Bedaquiline with Delamanid and Bedaquiline without Delamanid on Efficacy and Safety in Multidrug-resistant Tuberculosis Patients: Implementation in Dr. Soetomo General Academic Hospital, Indonesia.

Autor:	Soedarsono S; Department of Internal Medicine, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.; Department of Pulmonology and Respiratory Medicine, Airlangga University, Surabaya, Indonesia., Mertaniasih NM; Tuberculosis Study Group, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia.; Department of Clinical Microbiology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia., Kusmiati T; Department of Pulmonology and Respiratory Medicine, Airlangga University, Surabaya, Indonesia., Permatasari A; Department of Pulmonology and Respiratory Medicine, Airlangga University, Surabaya, Indonesia., Subay S; Department of Pulmonology and Respiratory Medicine, Airlangga University, Surabaya, Indonesia., Adiono SH; Department of Pulmonology and Respiratory Medicine, Airlangga University, Surabaya, Indonesia.
Jazyk:	angličtina
Zdroj:	International journal of mycobacteriology [Int J Mycobacteriol] 2024 Apr 01; Vol. 13 (2), pp. 140-146. Date of Electronic Publication: 2024 Jun 15.
DOI:	10.4103/ijmy.ijmy_88_24
Abstrakt:	Background: Bedaquiline is one of the core drugs used to treat multidrug-resistant TB (MDR-TB). Delamanid is one of the companion drugs in group C which is used to complete the treatment regimen when drugs in groups A and B can not be used. This study was conducted to analyze the efficacy and safety between individual regimens containing bedaquiline with delamanid and bedaquiline without delamanid. Methods: This was an observational analytic study with a retrospective design in MDR-TB patients treated with individual regimens containing bedaquiline with delamanid (bedaquiline-delamanid group) and bedaquiline without delamanid (bedaquiline group). Efficacy was measured according to the time to Acid Fast Bacilli (AFB) conversion and Mycobacterium tuberculosis culture conversion, while safety was measured specifically on QTc interval prolongation. Results: The median (range) time to AFB conversion in bedaquiline-delamanid group was faster than bedaquiline group, although there was no significant difference (1.5 (1-4) months vs. 1 (1-6) months, P=0.429), the median time to culture conversion in bedaquiline-delamanid group also faster than bedaquiline group, although there was no significant difference (1 (1-6) months vs. 2 (1-6) months, P=0.089). The incidence of QTc interval prolongation in bedaquiline-delamanid group was less than bedaquiline group, although there was no significant difference (26.9% vs. 40.3%, P=0.223). Conclusions: Individual regimens containing bedaquiline with delamanid was proven to provide similar efficacy and safety profiles with individual regimens containing bedaquiline without delamanid. Delamanid should be preferred when selecting drugs to complete the treatment regimen when drugs in groups A and B can not be used. (Copyright © 2024 Copyright: © 2024 International Journal of Mycobacteriology.)
Databáze:	MEDLINE
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