Insights into RC time curve fit analysis of pulmonary artery pressure decay.

Autor: Manouras A; Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, Stockholm, Sweden. aristomenis.manouras@ki.se.; Department of Medicine, Solna Karolinska Institutet, 17177, Stockholm, Sweden. aristomenis.manouras@ki.se., Lund LH; Heart and Vascular Center, Unit of Heart Failure, Arrhythmia and GUCH, Karolinska University Hospital, Stockholm, Sweden.; Department of Medicine, Solna Karolinska Institutet, 17177, Stockholm, Sweden., Nagy AI; Department of Medicine, Solna Karolinska Institutet, 17177, Stockholm, Sweden.; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Johnson J; Centre for Fetal Medicine Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2024 Jun 25; Vol. 24 (1), pp. 295. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1186/s12890-024-03107-5
Abstrakt: The notion of a constant relationship between resistance and capacitance (RC time) in the pulmonary circulation has been challenged by more recent research. The RC time can be obtained using either a simplified empirical approach or a semilogarithmic equation. Although direct curve-fit analysis is a feasible and ostensibly reference approach for RC analysis, it remains largely unexplored. We aimed to study the relationship between various RC methods in different states of pulmonary hemodynamics. Methods In total, 182 patients underwent clinically indicated right heart catheterization. The pressure curves were exported and processed using the MATLAB software. We calculated the RC time using the empirical method (RC EST ), semilogarithmic approach (RC SL ), and direct measurement of curve fit (RC FIT ). Results Among 182 patients, 137 had pulmonary hypertension due to left heart disease (PH-LHD), 35 had pulmonary arterial hypertension (PAH), and 10 demonstrated normal hemodynamics (non-PH). RC EST consistently overestimated the RC FIT and RC SL measurements by a mean of 75%. With all three methods, the RC values were longer in the PAH (RC FIT  = 0.36 ± 0.14 s) than in the PH-LHD (0.27 ± 0.1 s) and non-PH (0.27 ± 0.09 s) groups (p < 0.001). Although the RC SL and RC FIT values were similar among the three subgroups, they exhibited broad limits of agreement. Finally, the RC EST demonstrated a strong discriminatory ability (AUC = 0.86, p < 0.001, CI = 0.79-0.93) in identifying PAH. Conclusion RC time in PAH patients was substantially prolonged compared to that in PH-LHD and non-PH patients. The use of the empirical formula yielded systematic RC overestimation. In contrast, the semilogarithmic analysis provided reliable RC estimates, particularly for group comparisons.
(© 2024. The Author(s).)
Databáze: MEDLINE
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