Fusobacterium Detected in Barrett's Esophagus and Esophageal Adenocarcinoma Tissues.

Autor: Tahara T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Shijimaya T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Yamazaki J; Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; One Health Research Center, Hokkaido University, Sapporo, Japan., Kobayashi S; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Horitani A; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Matsumoto Y; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Nakamura N; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Okazaki T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Takahashi Y; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Tomiyama T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Honzawa Y; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Fukata N; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Fukui T; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan., Naganuma M; Third department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
Jazyk: angličtina
Zdroj: Cancer investigation [Cancer Invest] 2024 Jul; Vol. 42 (6), pp. 469-477. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1080/07357907.2024.2359980
Abstrakt: We examined Fusobacterium nucreatum ( F. nucleatum ) and whole Fusobacterium species ( Pan-fusobacterium ) in non-neoplastic Barrett's esophagus (BE) from patients without cancer ( n  = 67; N group), with esophageal adenocarcinoma (EAC) ( n  = 27) and EAC tissue ( n  = 22). F. nucleatum was only detectable in 22.7% of EAC tissue. Pan-fusobacterium was enriched in EAC tissue and associated with aggressive clinicopathological features. Amount of Pan-fusobacterium in non-neoplastic BE was correlated with presence of hital hernia and telomere shortening. The result suggested potential association of Fusobacterium species in EAC and BE, featuring clinicpathological and molecular features.
Databáze: MEDLINE