Acute exercise activates the AHR in peripheral blood mononuclear cells in an intensity-dependent manner.

Autor:	Joisten N; Division of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, Technical University Dortmund, Dortmund, Germany.; Division of Exercise and Movement Science, Institute for Sport Science, University of Göttingen, Göttingen, Germany., Walzik D; Division of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, Technical University Dortmund, Dortmund, Germany., Schenk A; Division of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, Technical University Dortmund, Dortmund, Germany., Metcalfe AJ; Chest Unit, Centre for Human and Applied Physiological Sciences (CHAPS), Denmark Hill Campus, King's College Hospital, King's College London, London, United Kingdom., Belen S; Division of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, Technical University Dortmund, Dortmund, Germany., Schaaf K; Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany., Jacko D; Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany., Gehlert S; Department for Biosciences of Sports, Institute of Sports Science, University of Hildesheim, Hildesheim, Germany., Spiliopoulou P; Sports Performance Laboratory, School of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece., Garzinsky AM; Center of Preventive Doping Research/Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Thevis M; Center of Preventive Doping Research/Institute of Biochemistry, German Sport University Cologne, Cologne, Germany., Rappelt L; Department of Intervention Research in Exercise Training, German Sport University Cologne, Cologne, Germany., Donath L; Department of Intervention Research in Exercise Training, German Sport University Cologne, Cologne, Germany., Meuth SG; Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Bloch W; Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany., Zimmer P; Division of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, Technical University Dortmund, Dortmund, Germany.
Jazyk:	angličtina
Zdroj:	American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2024 Aug 01; Vol. 327 (2), pp. C438-C445. Date of Electronic Publication: 2024 Jun 24.
DOI:	10.1152/ajpcell.00282.2024
Abstrakt:	The kynurenine pathway (KP) of tryptophan degradation generates several metabolites such as kynurenine (KYN) or kynurenic acid (KA) that serve as endogenous ligands of the aryl hydrocarbon receptor (AHR). Due to its distinct biological roles particularly modulating the immune system, the AHR is a current therapeutic target across different inflammation-related diseases. Here, we show an acute exercise-induced increase in AHR ligand availability on a systemic level and a kynurenine pathway activation in peripheral blood mononuclear cells (PBMCs). Concurrently, the AHR is activated in PBMCs following acute exercise. Exercise effects on both, kynurenic acid and AHR activation in PBMCs were greater in response to high-intensity interval exercise (HIIE) (50 min, six 3-min intervals at 90% V̇o 2peak , and 3-min intervals at 50% V̇o 2peak in between) compared with workload-matched moderate-intensity continuous exercise (MICE) (50 min). In conclusion, these data indicate a novel mechanistic link in how exercise modulates the immune system through the kynurenine pathway-AHR axis, potentially underlying exercise-induced benefits in various chronic diseases. NEW & NOTEWORTHY The findings of this study show that acute endurance exercise activates a receptor that has been described to integrate metabolic signals into the immune system. We uncover a potential mechanistic link on how exercise modulates the immune system through the kynurenine pathway-AHR axis, potentially underlying exercise-induced benefits in various chronic diseases and of relevance for other cell types.
Databáze:	MEDLINE
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