NR0B2 re-educates myeloid immune cells to reduce regulatory T cell expansion and progression of breast and other solid tumors.
Autor: | Vidana Gamage HE; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Shahoei SH; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Wang Y; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Jacquin E; INSERM, U1231, Dijon, France., Weisser E; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Bautista RO; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Henn MA; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Schane CP; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Nelczyk AT; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Ma L; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Das Gupta A; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Bendre SV; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Nguyen T; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Tiwari S; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Tjoanda E; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Krawczynska N; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois, USA., He S; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA., Albright ST; Department of Chemistry, University of Illinois at Urbana-Champaign, Illinois, USA., Farmer R; Department of Chemistry, University of Illinois at Urbana-Champaign, Illinois, USA., Smith AJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Illinois, USA., Fink EC; Department of Cancer Biology, Loyola University Chicago Health Sciences Campus, Illinois, USA., Chen H; Food Science & Human Nutrition, University of Illinois at Urbana-Champaign, Illinois, USA., Sverdlov M; Research Histology and Tissue Imaging Core, University of Illinois at Chicago, Illinois, USA., Gann PH; Research Histology and Tissue Imaging Core, University of Illinois at Chicago, Illinois, USA; Department of Pathology, University of Illinois at Chicago, Illinois, USA., Boidot R; Unit of Molecular Biology, Department of Biology and Pathology of Tumors, Georges-Francois Leclerc Cancer Center, Dijon, France; ICMUB UMR CNRS 6302, Dijon, France., Vegran F; INSERM, U1231, Dijon, France., Fanning SW; Department of Cancer Biology, Loyola University Chicago Health Sciences Campus, Illinois, USA., Hergenrother PJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Illinois, USA; Carl R. Woese Institute for Genomic Biology- Anticancer Discovery from Pets to People, University of Illinois at Urbana-Champaign, Illinois, USA; Cancer Center at Illinois, University of Illinois Urbana-Champaign, University of Illinois at Urbana-Champaign, Illinois, USA., Apetoh L; INSERM, U1231, Dijon, France., Nelson ER; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Illinois, USA; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois, USA; Carl R. Woese Institute for Genomic Biology- Anticancer Discovery from Pets to People, University of Illinois at Urbana-Champaign, Illinois, USA; Cancer Center at Illinois, University of Illinois Urbana-Champaign, University of Illinois at Urbana-Champaign, Illinois, USA; Division of Nutritional Sciences, University of Illinois Urbana-Champaign, University of Illinois at Urbana-Champaign, Illinois, USA. Electronic address: enels@illinois.edu. |
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Jazyk: | angličtina |
Zdroj: | Cancer letters [Cancer Lett] 2024 Aug 10; Vol. 597, pp. 217042. Date of Electronic Publication: 2024 Jun 20. |
DOI: | 10.1016/j.canlet.2024.217042 |
Abstrakt: | Although survival from breast cancer has dramatically increased, many will develop recurrent, metastatic disease. Unfortunately, survival for this stage of disease remains very low. Activating the immune system has incredible promise since it has the potential to be curative. However, immune checkpoint blockade (ICB) which works through T cells has been largely disappointing for metastatic breast cancer. One reason for this is a suppressive myeloid immune compartment that is unaffected by ICB. Cholesterol metabolism and proteins involved in cholesterol homeostasis play important regulatory roles in myeloid cells. Here, we demonstrate that NR0B2, a nuclear receptor involved in negative feedback of cholesterol metabolism, works in several myeloid cell types to impair subsequent expansion of regulatory T cells (T Competing Interests: Declaration of competing interest ERN, PJN, SA, RF, HEVG and SHS have filed a patent describing DSHN-OMe and its use targeting NR0B2. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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