Prenatal exposure to air pollution and maternal depression: Combined effects on brain aging and mental health in young adulthood.
| Autor: | Jáni M; Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Psychiatry, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czech Republic., Mikeš O; RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic., Marecek R; Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic., Brazdil M; Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic., Mareckova K; Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Electronic address: klara.mareckova@ceitec.muni.cz. |
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| Jazyk: | angličtina |
| Zdroj: | Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2024 Aug 30; Vol. 134, pp. 111062. Date of Electronic Publication: 2024 Jun 19. |
| DOI: | 10.1016/j.pnpbp.2024.111062 |
| Abstrakt: | Introduction: Both maternal depression problems during pregnancy and prenatal exposure to air pollution have been associated with changes in the brain as well as worse mood and anxiety in the offspring in adulthood. However, it is not clear whether these effects are independent or whether and how they might interact and impact the brain age and mental health of the young adult offspring. Methods: A total of 202 mother-child dyads from a prenatal birth cohort were assessed for maternal depression during pregnancy through self-report questionnaires administered in the early 90s, exposure to air pollutants (Sulfur dioxide [SO2], nitrogen oxides [NOx], and suspended particle matter [SPM]) during each trimester based on maternal address and air quality data, mental health of the young adult offspring (28-30 years of age; 52% men, all of European ancestry) using self-report questionnaires for depression (Beck Depression Inventory), mood dysregulation (Profile of Mood States), anxiety (State-Trait Anxiety Inventory), and psychotic symptoms (Schizotypal Personality Questionnaire), and brain age, estimated from structural magnetic resonance imaging (MRI) and previously published neuroanatomical age prediction model using cortical thickness maps. The brain age gap estimate (BrainAGE) was computed by subtracting structural brain age from chronological age. Trajectories of exposure to air pollution during pregnancy were assessed using Growth Mixture Modeling. The interactions of prenatal depression and prenatal exposure to air pollutants on adult mental health and BrainAGE were assessed using hierarchical linear regression. Results: We revealed two distinct trajectories of exposure to air pollution during pregnancy: "early exposure," characterized by high exposure during the first trimester, followed by a steady decrease, and "late exposure," characterized by low exposure during the first trimester, followed by a steady increase in the exposure during the subsequent trimesters. Maternal depression during the first half of pregnancy interacted with NO Conclusions: Our findings provide the first evidence of the combined effects of prenatal exposure to air pollution and maternal depression on mental health outcomes and brain age in young adult offspring. Moreover, they point out the importance of the timing and trajectory of the exposure during prenatal development. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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