Charting the course for improved outcomes in chronic critical illness: therapeutic strategies for persistent inflammation, immunosuppression, and catabolism syndrome (PICS).

Autor:	Polcz VE; Department of Surgery, University of Florida, Gainesville, FL, USA., Barrios EL; Department of Surgery, University of Florida, Gainesville, FL, USA., Larson SD; Department of Surgery, University of Florida, Gainesville, FL, USA., Efron PA; Department of Surgery, University of Florida, Gainesville, FL, USA., Rincon JC; Department of Surgery, University of Florida, Gainesville, FL, USA. Electronic address: jaimar.rincon@surgery.ufl.edu.
Jazyk:	angličtina
Zdroj:	British journal of anaesthesia [Br J Anaesth] 2024 Aug; Vol. 133 (2), pp. 260-263. Date of Electronic Publication: 2024 Jun 19.
DOI:	10.1016/j.bja.2024.05.005
Abstrakt:	Enhanced critical care delivery has led to improved survival rates in critically ill patients, yet sepsis remains a leading cause of multiorgan failure with variable recovery outcomes. Chronic critical illness, characterised by prolonged ICU stays and persistent end-organ dysfunction, presents a significant challenge in patient management, often requiring multifaceted interventions. Recent research, highlighted in a comprehensive review in the British Journal of Anaesthesia, focuses on addressing the pathophysiological drivers of chronic critical illness, such as persistent inflammation, immunosuppression, and catabolism, through targeted therapeutic strategies including immunomodulation, muscle wasting prevention, nutritional support, and microbiome modulation. Although promising avenues exist, challenges remain in patient heterogeneity, treatment timing, and the need for multimodal approaches. (Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu