Aqueous-Aqueous Triboelectric Nanogenerators Empowered Multifunctional Wound Healing System with Intensified Current Output for Accelerating Infected Wound Repair.

Autor: Wang W; School of Pharmacy, Qingdao University, Qingdao, 266071, China., Fu C; College of Physics, Qingdao University, Qingdao, 266071, China., Du Y; College of Physics, Qingdao University, Qingdao, 266071, China., Zheng H; School of Pharmacy, Qingdao University, Qingdao, 266071, China., Zhang Y; Guangdong Key Laboratory of Biomedical Measurements and Ultrasound School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, Guangdong, 518055, China., Song Y; State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China., Sun W; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, 266113, China., Wang X; College of Physics, Qingdao University, Qingdao, 266071, China., Ma Q; School of Pharmacy, Qingdao University, Qingdao, 266071, China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Jun 19, pp. e2401676. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1002/adhm.202401676
Abstrakt: Triboelectric nanogenerators (TENGs) have emerged as promising devices for generating self-powered therapeutic electrical stimulation over multiple aspects of wound healing. However, the challenge of achieving full 100% contact in conventional TENGs presents a substantial hurdle in the quest for higher current output, which is crucial for further improving healing efficacy. Here, a novel multifunctional wound healing system is presented by integrating the aqueous-aqueous triboelectric nanogenerators (A-A TENGs) with a functionalized conductive hydrogel, aimed at advancing infected wound therapy. The A-A TENGs are founded on a principle of 100% contact interface and efficient post-contact separation of the immiscible interface within the aqueous two-phase system (ATPS), enhancing charge transfer and subsequently increasing current performance. Leveraging this intensified current output, this system demonstrates efficient therapeutic efficacies over infected wounds both in vitro and in vivo, including stimulating fibroblast migration and proliferation, boosting angiogenesis, enhancing collagen deposition, eradicating bacteria, and reducing inflammatory cells. Moreover, the conductive hydrogel ensures the uniformity and integrity of the electric field covering the wound site, and exhibits multiple synergistic therapeutic effects. With the capability to realize accelerated wound healing, the developed "A-A TENGs empowered multifunctional wound healing system" presenting an excellent prospect in clinical wound therapy.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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