Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk.

Autor:	de Luis Roman D; Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain.; Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain., García Almeida JM; Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain., Bellido Guerrero D; Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de Ferrol (CHUF), 15405 Ferrol, A Coruña, Spain., Guzmán Rolo G; Medical Department, Abbott Laboratories, 28050 Madrid, Spain., Martín A; Medical Department, Abbott Laboratories, 28050 Madrid, Spain., Primo Martín D; Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain.; Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain., García-Delgado Y; Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular-Materno Infantil, 35016 Gran Canaria, Spain., Guirado-Peláez P; Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Málaga, Spain., Palmas F; Endocrinology and Nutrition Department, Hospital Universitari Vall D'Hebron, 08036 Barcelona, Spain., Tejera Pérez C; Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de Ferrol (CHUF), 15405 Ferrol, A Coruña, Spain.; Epigenomics in Endocrinology and Nutrition Group, Santiago Health Research Institute (IDIS), 34113 Santiago de Compostela, Spain., García Olivares M; Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Málaga, Spain.; Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.; Department of Medicine and Surgery, Malaga University, 29010 Malaga, Spain., Maíz Jiménez M; Department of Endocrinology and Nutrition, University Hospital 12 de Octubre, 28041 Madrid, Spain., Bretón Lesmes I; Endocrinology and Nutrition Unit, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Alzás Teomiro CM; Reina Sofía University Hospital, 14004 Córdoba, Spain., Guardia Baena JM; Service of Endocrinology and Nutrition, University Hospital Virgen de las Nieves, 41013 Granada, Spain., Calles Romero LA; Endocrinology and Nutrition Service, Basurto University Hospital, 48903 Bilbao, Spain., Prior-Sánchez I; Endocrinology Service, Complejo Hospitalario de Jaén, 23007 Jaén, Spain., García-Luna PP; Endocrinology and Nutrition Clinical Management Unit, Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC/University of Seville, 41013 Seville, Spain., González Pacheco M; Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.; Biomedical Research and Innovation Institute of Cádiz (INiBICA), 11009 Cádiz, Spain., Martínez-Olmos MÁ; Division of Endocrinology and Nutrition, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain.; Molecular Endocrinology Research Group, Health Research Institute of Santiago de Compostela-IDIS, 15706 Santiago de Compostela, Spain.; CIBERObn, National Health Institute Carlos III, 28031 Madrid, Spain., Alabadí B; Service of Endocrinology and Nutrition, Hospital Clínico Universitario of Valencia, 46010 Valencia, Spain.; INCLIVA Biomedical Research Institute, 46010 Valencia, Spain., Alcántara-Aragón V; Endocrinology and Nutrition Department, Marqués de Valdecilla University Hospital, 39008 Santander, Spain., Palma Milla S; Clinical Nutrition and Dietetics Unit, Endocrinology and Nutrition Service, University Hospital of La Paz, 28046 Madrid, Spain., Martín Folgueras T; Endocrinology and Nutrition Service, Hospital Universitario de Canarias, 38320 Tenerife, Spain., Micó García A; Endocrinology and Nutrition Service, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain., Molina-Baena B; Deparment of Endocrinology and Nutrition, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain., Rendón Barragán H; Endocrinology and Nutrition, FEA Endocrinology and Nutrition, Navarra University Hospital, 31008 Pamplona, Spain., Rodríguez de Vera Gómez P; Endocrinology and Nutrition Service, Virgen Macarena University Hospital, 41009 Seville, Spain., Riestra Fernández M; Endocrinology Service, Cabueñes University Hospital, 33394 Gijón, Spain.; Health Research Institute of the Principality of Asturias (ISPA), 33011 Oviedo, Spain., Jiménez Portilla A; Endocrinology and Nutrition Service, Consorci Hospital General Universitari de València, 46014 Valencia, Spain., López-Gómez JJ; Endocrinology and Nutrition Department, Clinical Universitary Hospital of Valladolid, 47003 Valladolid, Spain.; Investigation Centre Endocrinology and Nutrition, Faculty of Medicine, University of Valladolid, 47003 Valladolid, Spain., Pérez Martín N; Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario Insular-Materno Infantil, 35016 Gran Canaria, Spain., Montero Madrid N; Department of Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.; Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Málaga, Spain.; Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, 29010 Málaga, Spain., Zabalegui Eguinoa A; Endocrinology and Nutrition Department, Hospital Universitari Vall D'Hebron, 08036 Barcelona, Spain., Porca Fernández C; Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de Ferrol (CHUF), 15405 Ferrol, A Coruña, Spain.; Epigenomics in Endocrinology and Nutrition Group, Santiago Health Research Institute (IDIS), 34113 Santiago de Compostela, Spain.; Professor Novoa Santos Foundation, 15405 A Coruña, Spain., Tapia Guerrero MJ; Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Málaga, Spain.; Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain., Ruiz Aguado M; Department of Endocrinology and Nutrition, University Hospital 12 de Octubre, 28041 Madrid, Spain.; i+12 Research Institute, 28041 Madrid, Spain., Velasco Gimeno C; Endocrinology and Nutrition Unit, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain., Herrera Martínez AD; Reina Sofía University Hospital, 14004 Córdoba, Spain.; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain., Novo Rodríguez M; Service of Endocrinology and Nutrition, University Hospital Virgen de las Nieves, 41013 Granada, Spain., Iglesias Hernández NC; Endocrinology and Nutrition Service, Basurto University Hospital, 48903 Bilbao, Spain., de Damas Medina M; Endocrinology Service, Complejo Hospitalario de Jaén, 23007 Jaén, Spain., González Navarro I; Endocrinology and Nutrition Clinical Management Unit, Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío/CSIC/University of Seville, 41013 Seville, Spain., Vílchez López FJ; Endocrinology and Nutrition Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.; Biomedical Research and Innovation Institute of Cádiz (INiBICA), 11009 Cádiz, Spain., Fernández-Pombo A; Division of Endocrinology and Nutrition, University Clinical Hospital of Santiago de Compostela, 15706 Santiago de Compostela, Spain., Olveira G; Institute of Biomedical Research in Malaga (IBIMA)-Bionand Platform, University of Malaga, 29590 Málaga, Spain.; Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.; Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, 29010 Málaga, Spain.; CIBER of Diabetes and Associated Metabolic Diseases, Carlos III Health Institute, 28029 Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 May 21; Vol. 16 (11). Date of Electronic Publication: 2024 May 21.
DOI:	10.3390/nu16111552
Abstrakt:	Background: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound of the rectus femoris for detecting sarcopenia in hospitalized patients at risk of malnutrition and to define cut-off values of ultrasound measures. Methods: Patients at risk of malnutrition according to the Malnutrition Universal Screening Tool (MUST) underwent handgrip dynamometry, bioelectrical impedance analysis (BIA), a Timed Up and Go (TUG) test, and rectus femoris ultrasound studies. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were used to define categories of sarcopenia (at risk, probable, confirmed, severe). Receiver operating characteristic (ROC) and area under the curve (AUC) analyses were used to determine the optimal diagnostic sensitivity, specificity, and predictive values of cut-off points of the ultrasound measures for the detection of risk of sarcopenia and probable, confirmed, and severe sarcopenia. Results: A total of 1000 subjects were included and 991 of them (58.9% men, mean age 58.5 years) were evaluated. Risk of sarcopenia was detected in 9.6% patients, probable sarcopenia in 14%, confirmed sarcopenia in 9.7%, and severe sarcopenia in 3.9%, with significant differences in the distribution of groups between men and women ( p < 0.0001). The cross-sectional area (CSA) of the rectus femoris showed a significantly positive correlation with body cell mass of BIA and handgrip strength, and a significant negative correlation with TUG. Cut-off values were similar within each category of sarcopenia, ranging between 2.40 cm 2 and 3.66 cm 2 for CSA, 32.57 mm and 40.21 mm for the X -axis, and 7.85 mm and 10.4 mm for the Y -axis. In general, these cut-off values showed high sensitivities, particularly for the categories of confirmed and severe sarcopenia, with male patients also showing better sensitivities than women. Conclusions: Sarcopenia in hospitalized patients at risk of malnutrition was high. Cut-off values for the better sensitivities and specificities of ultrasound measures of the rectus femoris are established. The use of ultrasound of the rectus femoris could be used for the prediction of sarcopenia and be useful to integrate nutritional study into real clinical practice. Competing Interests: G.G.R. and A.M are full employees of Abbott Laboratories. None of the remaining authors have any conflicts of interest. The authors declare that the project was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Databáze:	MEDLINE
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