Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons.

Autor:	Aerts T; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium., Boonen A; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium., Geenen L; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium., Stulens A; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium., Masin L; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Neural Circuit Development and Regeneration, KU Leuven , Leuven 3000, Belgium., Pancho A; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium.; Developmental Genetics, Department of Biomedicine, University of Basel , Basel 4058, Switzerland., Francis A; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium., Pepermans E; Centre for Proteomics, University of Antwerp , Antwerp, Belgium., Baggerman G; Centre for Proteomics, University of Antwerp , Antwerp, Belgium.; Department of Computer Science, University of Antwerp , Antwerp, Belgium., Van Roy F; Faculty of Science, Department of Biomedical Molecular Biology; Inflammation Research Center, VIB, Ghent University , Cancer Research Institute Ghent (CRIG) 9000, Belgium., Wöhr M; Faculty of Psychology and Educational Sciences, Research Unit Brain and Cognition, Laboratory of Biological Psychology, Social and Affective Neuroscience Research Group, KU Leuven , Leuven 3000, Belgium.; KU Leuven, Leuven Brain Institute , Leuven 3000, Belgium.; Faculty of Psychology, Experimental and Biological Psychology, Behavioral Neuroscience, Philipps-University of Marburg , Marburg 35032, Germany.; Center for Mind, Brain and Behavior, Philipps-University of Marburg , Marburg 35032, Germany., Seuntjens E; Faculty of Science, Department of Biology, Division of Animal Physiology and Neurobiology, Lab of Developmental Neurobiology, KU Leuven , Leuven 3000, Belgium.; KU Leuven, Leuven Brain Institute , Leuven 3000, Belgium.; KU Leuven, Leuven Institute for Single Cell Omics , Leuven 3000, Belgium.
Jazyk:	angličtina
Zdroj:	Open biology [Open Biol] 2024 Jun; Vol. 14 (6), pp. 240113. Date of Electronic Publication: 2024 Jun 19.
DOI:	10.1098/rsob.240113
Abstrakt:	Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions associated with deficits in social interaction and communication, together with repetitive behaviours. The cell adhesion molecule protocadherin10 ( PCDH10 ) is linked to ASD in humans. Pcdh10 is expressed in the nervous system during embryonic and early postnatal development and is important for neural circuit formation. In mice, strong expression of Pcdh10 in the ganglionic eminences and in the basolateral complex (BLC) of the amygdala was observed at mid and late embryonic stages, respectively. Both inhibitory and excitatory neurons expressed Pcdh10 in the BLC at perinatal stages and vocalization-related genes were enriched in Pcdh10 -expressing neurons in adult mice. An epitope-tagged Pcdh10 -HAV5 mouse line revealed endogenous interactions of PCDH10 with synaptic proteins in the young postnatal telencephalon. Nuanced socio-affective communication changes in call emission rates, acoustic features and call subtype clustering were primarily observed in heterozygous pups of a conditional knockout (cKO) with selective deletion of Pcdh10 in Gsh2 -lineage interneurons. These changes were less prominent in heterozygous ubiquitous Pcdh10 KO pups, suggesting that altered anxiety levels associated with Gsh2 -lineage interneuron functioning might drive the behavioural effects. Together, loss of Pcdh10 specifically in interneurons contributes to behavioural alterations in socio-affective communication with relevance to ASD.
Databáze:	MEDLINE
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