Effect of aerosol inhalation of budesonide on respiratory symptoms and inflammatory factors in patients with asthma: a meta-analysis.
| Autor: | Xu J; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China., Kou L; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China., Bai D; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China., Lian P; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China., Na S; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China., Zhang L; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China., Gang L; EICU of Zhongshan Hospital Affiliated to Dalian University, Dalian, China. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2024 Nov; Vol. 61 (11), pp. 1581-1589. Date of Electronic Publication: 2024 Jul 05. |
| DOI: | 10.1080/02770903.2024.2368201 |
| Abstrakt: | Objective: To review the efficacy, symptoms, inflammatory factors and pulmonary function of different doses of budesonide aerosol inhalation in the treatment of patients with asthma. Methods: The Chinese and English literature databases were searched with "Effects of different doses of budesonide aerosol inhalation on the efficacy, lung function, inflammation, symptoms and adverse reactions in patients with asthma" as the search direction, and a Meta-analysis was performed. Results: Compared with the low dose group, the efficacy, PEF and FEV1 were significantly increased and the clinical symptom score, TNF-α and IL-4 were significantly decreased in the high dose group ( p < 0.05). There was no significant difference in IFN-γ level and the incidence of adverse reactions between the two groups ( p > 0.05). Conclusion: High-dose budesonide aerosol inhalation therapy can improve the efficacy and lung function of patients, reduce inflammation and clinical symptoms, and does not increase the risk of adverse reactions, which is worthy of clinical promotion. |
| Databáze: | MEDLINE |
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